How a narrow-spectrum antibiotic takes aim at C. diff

Most antibiotics are double-edged swords — while killing bacteria, they also decimate beneficial bacteria and change the composition of the gut microbiome. The answer to this problem might be narrow-spectrum antibiotics. UW–Madison scientists took a close look at one such antibiotic using cryo-EM. Their findings are detailed in Nature.

Venturelli Lab receives R21 to research antibiotic resistant genes

Biochemistry Assistant Professor Ophelia Venturelli has been awarded an Exploratory/ Developmental Research Grant (R21) by the National Institutes of Health (NIH). The award is in support of the development of new methods to uncover associations between antibiotic resistance genes and microbial hosts in the human gut microbiome. The rise and spread of bacteria that are …

Chasing the tail: Biochemists zone in on bacterial transporter’s tip as its secret to antibiotic resistance

Professor Henzler-Wildman and her team have found that proton and drug movements are not as strictly coupled as they thought in EmrE. This transporter can actually also move drugs and protons across the membrane in the same direction, as well as the opposite direction — introducing the option of moving molecules both into or out of the cell.