A deleterious bacterial infection can take hold when the diverse community of bacteria in the gut microbiome are killed with antibiotics.
Xinyun (Sherry) Cao, a postdoctoral researcher in the Landick Lab, was awarded a Pathway to Independence Award (K99/R00) from the NIH.
Most antibiotics are double-edged swords — while killing bacteria, they also decimate beneficial bacteria and change the composition of the gut microbiome. The answer to this problem might be narrow-spectrum antibiotics. UW–Madison scientists took a close look at one such antibiotic using cryo-EM. Their findings are detailed in Nature.
Clostridioides difficile, an antibiotic-resistant intestinal pathogen, is the leading cause of hospital-acquired infections in the United States. Treatment of a Clostridioides difficile, also known as C. difficile, infection may include courses of antibiotics or fecal transplants in which the fecal sample of a healthy donor is transplanted into a patient with C. difficile. These treatments …