Most antibiotics are double-edged swords — while killing bacteria, they also decimate beneficial bacteria and change the composition of the gut microbiome. The answer to this problem might be narrow-spectrum antibiotics. UW–Madison scientists took a close look at one such antibiotic using cryo-EM. Their findings are detailed in Nature.
RNAP
Scientists provide new insight on how gene expression is controlled
New research on transcriptional pausing, which helps control gene expression in cells, will aid in the understanding of the enzyme RNA polymerase — a key player in the process and an important drug target.