Most antibiotics are double-edged swords — while killing bacteria, they also decimate beneficial bacteria and change the composition of the gut microbiome. The answer to this problem might be narrow-spectrum antibiotics. UW–Madison scientists took a close look at one such antibiotic using cryo-EM. Their findings are detailed in Nature.
New research on transcriptional pausing, which helps control gene expression in cells, will aid in the understanding of the enzyme RNA polymerase — a key player in the process and an important drug target.