Researchers used Cryo-EM to precisely detail how bacterial proteins act like emergency first responders, repairing broken DNA on the fly.
Cryo-EM
Elizabeth Wright Named Vilas Associate
Biochemistry professor and Morgridge Institute for Research investigator Elizabeth Wright has been selected as a 2023-2024 Vilas Associate.
From ‘blobology’ to atomic precision: Wisconsin’s leadership on cryo-EM imaging
Cryo-electron microscopy drives a promising collaboration between the UW-Madison Department of Biochemistry and the Morgridge Institute.
Congressional staff tour cryo-EM research centers in biochemistry department
Legislative staff to members of Congress from the Wisconsin delegation toured UW–Madison the week of Aug. 14, 2022, including a stop at the Department of Biochemistry’s cryo-electron microscopy research centers.
Enzymes, proteins work together to tidy up tail ends of DNA in dividing cells
Biochemistry researchers have described the way an enzyme and proteins interact to maintain the protective caps, called telomeres, at the end of chromosomes, a new insight into how a human cell preserves the integrity of its DNA through repeated cell division.
New cryo-electron microscopy centers help UW researchers uncover mysteries of life
At the Steenbock Symposium on June 7 and 8, 2022, the University of Wisconsin–Madison Department of Biochemistry opened its doors in celebration of two new research centers that bring to campus advanced biomolecular imaging technology called cryo-electron microscopy.
Game-changer: New tech could transform biotechnology
The Joshua Coon Lab has united the power of two major tools in biotechnology. In research published April 27 in Nature Communications, the lab describes a game-changing advance that marries mass spectrometry and electron microscopy (EM). “This work is the culmination of a nearly five-year effort to couple mass spec technology to EM,” says Coon, …
SARS-CoV-2 research featured in Grow magazine
As part of the global effort to understand SARS-CoV-2 (the coronavirus that causes COVID-19), CALS scientists have pivoted their existing research projects, launched entirely new studies, and banded together to share knowledge and resources. Experts in the Department of Biochemistry are the linchpins of many of these efforts.
How a narrow-spectrum antibiotic takes aim at C. diff
Most antibiotics are double-edged swords — while killing bacteria, they also decimate beneficial bacteria and change the composition of the gut microbiome. The answer to this problem might be narrow-spectrum antibiotics. UW–Madison scientists took a close look at one such antibiotic using cryo-EM. Their findings are detailed in Nature.
Jae Yang receives 2022 Boyer Award
The Department of Biochemistry is pleased to announce Jae Yang as the winner of the 2022 Boyer Award for Postdoctoral Excellence in Biochemistry. The award recognizes and rewards excellence in research accomplishments in the Department of Biochemistry. A cryo-electron microscopist and virologist by training, Jae has developed and used innovative workflows and tools for cryo-electron …