Imaging is a powerful tool in many biochemists’ repertoire. The Department of Biochemistry is home to a large collection of equipment and facilities, including the Biochemistry Optical Core (BOC) and upcoming cryo-electron microscopy (cryo-EM) facility, that allows scientists to pursue their many imaging endeavors.
Research
Biochemists search for new weapon against bacterial disease
Biochemistry professor Srivatsan (“Vatsan”) Raman hopes to harness the power of phages — viruses that infect bacteria but leave humans unscathed. With help from a grant from the Bill and Melinda Gates Foundation, Raman’s team is designing phages to specifically target bacteria that are causing diseases in infants.
Cracking the code of coenzyme Q biosynthesis
Coenzyme Q is a vital cog in the body’s energy-producing machinery, a kind of chemical gateway in the conversion of food into cellular fuel. But six decades removed from its discovery, scientists still can’t describe exactly how and when it is made.
Chimpanzee deaths in Uganda pinned on human cold virus
In the wild, chimpanzees face any number of dire threats, ranging from poachers to predators to deforestation. That’s why scientists, investigating an outbreak of respiratory disease in a community of wild chimpanzees in Uganda’s Kibale National Park, were surprised and dismayed to discover that a human “common cold” virus known as rhinovirus C was killing healthy chimps.
Designer molecule points to treatment for diseases caused by DNA repeats
Researchers have designed a molecule that targets short sequences of DNA that repeat many times, including those that cause the rare but fatal disease Friedreich’s ataxia.
Crystallizing science, one protein at a time
It’s square one. It’s step one. It puts the “basic” in basic science. How ever you describe it, understanding protein structure and function through what’s called X-ray crystallography is an important approach in many areas of biochemistry, including drug design. And it’s a technique many researchers in the Department of Biochemistry at UW–Madison specialize in.
Students find passion in labs as Undergraduate Summer Research Scholars
Hannah Poe peers into a large microscope in the Hector F. DeLuca Biochemical Sciences Building, seeing not just florescent molecules of RNA, but also a future career in biochemistry research. Poe is about to start …
Cryo-EM facility coming to department to serve campus researchers
Structural biology and collaboration are two strong and enduring aspects of research at the University of Wisconsin–Madison. In keeping with this tradition, the Department of Biochemistry has led a concerted cross-campus effort to bring cryo-electron microscopy (cryo-EM) to campus.
For some plants, winter carries the keys to spring flowering
What happens to plants as they enter spring? What’s the science that governs the growing season for different plants? Plant biochemist Rick Amasino shares some answers in this Q&A.
Continuing a Legacy: Vitamin D Research in the 21st Century
The legacy of vitamin D research in the Department of Biochemistry at the University of Wisconsin–Madison runs deep — almost as deep as the vitamin’s involvement in a multitude of important processes in the body, …