A new antifungal molecule has the potential to harness Amphotericin B’s power against fungal infections while doing away with its toxicity.
antifungals
Scientists pinpoint structure of antifungal, challenge binding mechanism
Nearly seventy years after the discovery of Amphotericin B, scientists are still learning from this enigmatic drug. UW–Madison scientists, in collaboration with scientists at the University of Illinois at Urbana-Champaign and the National Institutes of Health (NIH), applied innovative nuclear magnetic resonance techniques to reveal the structure of Amphotericin B as it’s about to bind …