Forgotten molecules: The fruits of an emeritus professor’s 40-year career are contributing to the modern search for new medications

In the complicated process of drug discovery, scientists screen large collections of molecules in search of a range of properties that indicate they could be used as antibiotic, antifungal, or anticancer agents, or even neurological drugs. When compared to the types of molecules synthesized for drug discovery today, the old-school way in which biochemistry emeritus professor Laurens Anderson’s molecules were made gives them some unique properties, so they are taking on new significance.

Radiation-resistant E. coli evolved in the lab give view into DNA repair

In a study published online this month in the Journal of Bacteriology, biochemistry professor Michael Cox and his team describe blasting E. coli bacteria with ionizing radiation once a week, causing the bacteria to become radiation resistant. In doing so, they have uncovered genetic mutations and mechanisms underlying this resistance.