NIH funds R01 grant to study a model-guided design of next-generation bacterial therapeutics to treat cardiovascular disease

Ophelia Venturelli (Biochemistry) in collaboration with Philip Romero (Biochemistry) and Federico Rey (Bacteriology) were awarded an R01 grant through the National Institute of Biomedical Imaging and Bioengineering. The award will provide a total of $2.7M over four years. The team will develop computational modeling and optimization techniques to design next-generation bacterial therapeutics that sense major metabolites produced by gut microbiota and produce antimicrobial proteins to impact key gut microbiome produced metabolites that impact cardiovascular disease.

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Ophelia Venturelli and collaborators
From left to right: Ophelia Venturelli, Philip Romero, and Federico Rey.