Congratulations to David S. White, postdoc in the Hoskins Lab, who was recently awarded a Ruth L. Kirschstein Postdoctoral Fellowship (F32) from the NIH National Institute of General Medical Sciences (NIGMS). David’s award begins in December 2021 in the amount of $197,994 across three years.
In his project entitled “Quantitative and Predictive Analysis of 5’ Splice Site Recognition by U1 snRNP Using Massively Parallel Arrays” he will develop a method to select and remove introns from pre-mRNAs by the spliceosome, an essential step in eukaryotic gene expression. David and his collaborators will use high-throughput technology to measure interactions of human U1 small nuclear ribonucleoprotein (snRNP) with thousands of distinct 5’ splice sites to build quantitative and predictive models of intron selection, aiming to determine the effect of other splicing factors and U1 mutations on intron selection and test those models in vivo. This project is a collaboration between the Hoskins Lab at UW-Madison and the Herschlag Lab at Stanford University.
Aaron Hoskins shares that “David is clearly a rising star in biophysics and this fellowship helps pave the way for his research at the frontiers of quantitative analysis of RNA processing at the transcriptome scale.”