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The research projects in the Raines laboratory are designed to reveal how biological phenomena can be explained with the principles of chemistry. The hypotheses are far-reaching, and testing them requires the use of techniques and ideas from diverse disciplines. The ensuing broad/deep training is appropriate for scientists who want to perform innovative and meaningful research at the widening chemistry - biology interface.

Note: The Raines group is moving to MIT in summer 2017.

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Knockout of the Ribonuclease Inhibitor Gene Leaves Human Cells Vulnerable to Secretory Ribonucleases

Knockout of the Ribonuclease Inhibitor Gene Leaves Human Cells Vulnerable to Secretory Ribonucleases

A Boronic Acid Conjugate of Angiogenin that Shows ROS-Responsive Neuroprotective Activity

A Boronic Acid Conjugate of Angiogenin that Shows ROS-Responsive Neuroprotective Activity

Prolyl-4-Hydroxylase: Substrate Isosteres In Which an (E)- or (Z)-Alkene Replaces the Prolyl Peptide Bond

Prolyl-4-Hydroxylase: Substrate Isosteres In Which an (E)- or (Z)-Alkene Replaces the Prolyl Peptide Bond

Peptide Tessellation Yields Micrometre-scale Collagen Triple Helices

Peptide Tessellation Yields Micrometre-scale Collagen Triple Helices

Diazo Compounds: Versatile Tools for Chemical Biology

Diazo Compounds: Versatile Tools for Chemical Biology

n→π* Interactions Are Competitive with Hydrogen Bonds

n→π* Interactions Are Competitive with Hydrogen Bonds

Rapid Cycloaddition of a Diazo Compound with an Unstrained Dipolarophile

Rapid Cycloaddition of a Diazo Compound with an Unstrained Dipolarophile

Decreasing Distortion Energies without Strain: Diazo-selective 1,3-Dipolar Cycloadditions

Decreasing Distortion Energies without Strain: Diazo-selective 1,3-Dipolar Cycloadditions

Human Collagen Prolyl 4-Hydroxylase Is Activated by Ligands for Its Iron Center

Human Collagen Prolyl 4-Hydroxylase Is Activated by Ligands for Its Iron Center

Boronic Acid for the Traceless Delivery of Proteins into Cells

Boronic Acid for the Traceless Delivery of Proteins into Cells

1,3-Dipolar Cycloadditions of Diazo Compounds in the Presence of Azides

1,3-Dipolar Cycloadditions of Diazo Compounds in the Presence of Azides

Diazo Groups Endure Metabolism and Enable Chemoselectivity in cellulo

Diazo Groups Endure Metabolism and Enable Chemoselectivity in cellulo

Biomass to Furanics: Renewable Routes to Chemicals and Fuels

Biomass to Furanics: Renewable Routes to Chemicals and Fuels

Human Cancer Antigen Globo H Is a Cell-Surface Ligand for Human Ribonuclease 1

Human Cancer Antigen Globo H Is a Cell-Surface Ligand for Human Ribonuclease 1

Catalysis by the Tumor-Suppressor Enzymes PTEN and PTEN-L

Catalysis by the Tumor-Suppressor Enzymes PTEN and PTEN-L

Conformational Stability and Catalytic Activity of PTEN Variants Linked to Cancers and Autism Spectrum Disorders

Conformational Stability and Catalytic Activity of PTEN Variants Linked to Cancers and Autism Spectrum Disorders

Diazo Compounds for the Bioreversible Esterification of Proteins

Diazo Compounds for the Bioreversible Esterification of Proteins

Optimized Diazo Scaffold for Protein Esterification

Optimized Diazo Scaffold for Protein Esterification

Bright Building Blocks for Chemical Biology

Bright Building Blocks for Chemical Biology

Thioamides in the Collagen Triple Helix

Thioamides in the Collagen Triple Helix

Separation of Lignin from Corn Stover Hydrolysate with Quantitative Recovery of Ionic Liquid

Separation of Lignin from Corn Stover Hydrolysate with Quantitative Recovery of Ionic Liquid

Selective Inhibition of Prolyl 4-Hydroxylases by Bipyridinedicarboxylates

Selective Inhibition of Prolyl 4-Hydroxylases by Bipyridinedicarboxylates

Replacing a Single Atom Accelerates the Folding of a Protein and Increases its Thermostability

Replacing a Single Atom Accelerates the Folding of a Protein and Increases its Thermostability