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Research in the Butcher Laboratory is focused on understanding how RNA molecules regulate gene expression. We aim to understand the three-dimensional structure, function and dynamics of RNA. RNA plays a central role in many biologically important processes, including protein synthesis, pre-messenger RNA (pre-mRNA) splicing, chromosome maintenance and viral replication. RNA molecules directly regulate gene expression inside the cell in a number of fascinating ways.

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Photo of Butcher group 2017

The Butcher Lab, from left to right: Allison Didychuk, Sam Butcher, Eric Montemayor, Nimu Sidhu, Yuichiro Nomura, Matt Larson, Andy DeLaitsch. Not pictured: Stefani Lucarelli and Johanna Virta.

Image of structure of the Wild-type core of the yeast U6 snRNP

Structure of the Wild-type core of the yeast U6 snRNP (Montemayor et al., Acta Cryst. D, 2017)

Image of combined NMR/SAXS analysis of RNA structure

Combined NMR/SAXS analysis of RNA structure (Burke et al., 2012)

image of 1.7 Å X-ray diffraction data from crystals of the U6 snRNP core

1.7 Å X-ray diffraction data from crystals of the U6 snRNP core (Montemayor et al., NSMB 2014)

Image of recycling of U6 snRNA during pre-mRNA splicing

Recycling of U6 snRNA during pre-mRNA splicing

Image of structures of human (blue) and yeast (green) Usb1

Structures of human (blue) and yeast (green) Usb1

Image of mutations within the Prp24 electropositive groove reduce Prp24-mediated annealing of U4 and U6 snRNAs

Mutations within the Prp24 electropositive groove reduce Prp24-mediated annealing of U4 and U6 snRNAs. (Didychuk et al., Nucleic Acids Research, 2016)

Last Updated: Jul 12, 2017 - 1:09 PM