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Research in the Butcher Laboratory is focused on understanding how RNA molecules regulate gene expression. We aim to understand the three-dimensional structure, function and dynamics of RNA. RNA plays a central role in many biologically important processes, including protein synthesis, pre-messenger RNA (pre-mRNA) splicing, chromosome maintenance and viral replication. RNA molecules directly regulate gene expression inside the cell in a number of fascinating ways.

Photo of Butcher, Hoskins, Brow group

The Tri-Group (Butcher, Brow, and Hoskins) Labs unite for a picture (Fall 2015).

A small portion of the splicing cycle: recycling of U6.

A small portion of the splicing cycle: recycling of U6.

NMR and SAXS structure of U2/U6 snRNA (Burke 2012)

NMR and SAXS structure of U2/U6 snRNA (Burke 2012)