Enzyme Structure and Function

36th Steenbock Symposium - May 22, 2014 to May 24, 2014
Overture Center for the Performing Arts


Thursday, May 22, 2014

4:00pm – 8:00pm Registration Check-in and Attendee Services – Promenade Terrace

6:00pm – 8:00pm Welcome Reception – Promenade Hall

Friday, May 23, 2014

7:45am – 4:00pm Attendee Services – Promenade Terrace

7:45am – 8:45am Continental Breakfast – Promenade Terrace

8:45am Welcome and Opening Remarks – Promenade Hall
Ivan Rayment, Michael G. Rossmann Professor Biochemistry, Department of Biochemistry, University of Wisconsin - Madison

Session I – Promenade Hall
Chair: Christopher T. Walsh, Hamilton Kuhn Distinguished Professor, Harvard Medical School

9:00am - 9:30am Visualizing H/D Exchange Kinetics from the Backbone of Proteins, Mo’s Way
Richard N. Armstrong, Professor, Departments of Biochemistry and Chemistry, Vanderbilt University

9:30am - 10:00am Mobile Domain: The Sharpest Tool in the Enzyme Tool Box
Debra Dunaway-Mariano, Professor, Department of Chemistry & Chemical Biology, University of New Mexico

10:00am - 10:20am Break

Session II – Promenade Hall
Chair: Rowena G. Matthews, G. Robert Greenberg Distinguished University Professor of Biological Chemistry Emeritus, Senior Research Scientist Emeritus at the Life Sciences Institute, University of Michigan

10:30am - 11:00am Radical Reactions in Biology
JoAnne Stubbe, Novartis Professor of Chemistry, Professor of Biology, Department of Chemistry, Massachusetts Institute of Technology

11:00am - 11:30am Radical Enzymatic Transformations in tRNA Modification and Natural Product Biosynthesis
Vahe Bandarian, Associate Professor, Departments of Chemistry and Biochemistry, The University of Arizona

11:30am - 12:00pm A Radically Different Mechanism for Methylating Unactivated C-H Bonds
Squire J. Booker, Professor of Chemistry, Professor of Biochemistry and Molecular Biology, The Pennsylvania State University

12:00pm – 1:30pm Box Lunch – Promenade and Upper Lobbies

3:00pm – 6:00pm Poster Session
Cash bar available

Evening - enjoy dinner and Madison on your own

Saturday, May 24, 2014

8:00am – 5:00pm Attendee Services – Promenade Terrace

8:00am - 9:00am Continental Breakfast – Promenade Terrace

Session III – Promenade Hall
Chair: Dexter B. Northrop, Professor Emeritus, School of Pharmacy, University of Wisconsin - Madison

9:00am - 9:30am Specificity and Promiscuity in a Superfamily of Phosphatases
Karen N. Allen, Professor, Department of Chemistry, Boston University

9:30am - 10:00am Finding Homes for Orphan Enzymes
Frank M. Raushel, Distinguished Professor, Department of Chemistry, Texas A&M University

10:00am - 10:20am Break – Promenade Terrace

Session IV – Promenade Hall
Chair: Peter A. Tipton, Professor, Department of Biochemistry, University of Missouri

10:30am - 11:00am When Kinetic Isotope Effects Met Steady State Kinetics 
Judith P. Klinman, Chancellor’s Professor, Department of Chemistry, University of California – Berkeley

11:00am - 11:30am Equilibrium Perturbation: The Case of Isocitrate Lyase 
John S. Blanchard, Dan Danciger Professor of Biochemistry, Albert Einstein College of Medicine of Yeshiva University

11:30am - 12:00pm The Aromatic Amino Acid Hydrolases
Paul F. Fitzpatrick, Professor, Department of Biochemistry, University of Texas Health Science Center at San Antonio

12:15pm - 1:45pm Lunch – Overture Hall Main Lobby

Session V – Promenade Hall
Chair, George H. Reed, Professor Emeritus, Department of Biochemistry, University of Wisconsin - Madison

2:00pm - 2:30pm Kinetics, Kinetic Isotope Effects, Transition States and Drug Design
Vern L. Schramm, Professor and Ruth Merns Chair in Biochemistry, Albert Einstein College of Medicine of Yeshiva University

2:30pm - 3:00pm Case Studies of the Use of Steady-State Enzyme Kinetics in Drug Discovery
Thomas Meek, Vice President, GlaxoSmithKline

3:00pm - 3:30pm Break – Promenade Terrace

Session VI – Promenade Hall
Chair, Perry A. Frey, Robert H. Abeles Professor of Biochemistry Emeritus, Department of Biochemistry, University of Wisconsin - Madison

3:30pm - 4:00pm Structural Basis of the Regulation of Bacterial Acetyl-CoA Carboxylase
Grover L. Waldrop, Professor, Biochemistry and Molecular Biology Division, Department of Biological Sciences, Louisiana State University

4:00pm - 4:30pm To Be Announced
Nigel G. J. Richards, Professor and Chair, Department and Chemistry & Chemical Biology, Indiana University – Purdue University Indianapolis

4:30pm - 5:00pm Applying Mo Cleland’s Ideas to Phosphite Dehydrogenase
Wilfred van der Donk, Richard E. Heckert Professor of Chemistry, Professor, Institute for Genomic Biology, University of Illinois at Urbana-Champaign

7:00pm Social Hour – Promenade Lobby

7:45pm Closing Banquet – Overture Hall Main Lobby

Paul F. Cook, George Lynn Cross Emeritus Professor of Biochemistry, Department of Chemistry and Biochemistry, The University of Oklahoma
Philatelic Contributions of Wallace Cleland