BIOCHEMISTRY

Sunday, June 26th

3:00 – 5:00 PM Registration - South atrium

6:30 – 7:30 PM Reception - South atrium

7:30 – 7:45 PM Opening remarks - Forum

7:45 – 9:15 PM Keynote Session: Forum
Session Chair: David Cowburn

James Prestegard, University of Georgia
Combining NMR with Other Technologies: Chemokine Aggregation and GAG Interaction

Kevin Gardner, University of Texas Southwestern
Ligand-regulated Protein/Protein Interactions: Insights Provided by NMR into Nature’s Switches

Monday, June 27th

8:00 – 8:30 AM Light breakfast - South atrium

8:30 AM – 12:05 PM Morning session - Forum
Session Chair: Angela Gronenborn

Gerhard Wagner, Harvard University
Recent Development of NMR Experiments for Challenging Proteins

Cheryl Arrowsmith, University of Toronto
Molecular Recognition by Readers of the Histone Code        

Richard Vierstra, University of Wisconsin-Madison
Atomic Perspectives on Phytochrome Photoactivation and Signaling

David Cowburn, Albert Einstein College of Medicine
Intrinsically Disordered Segments – What Can NMR Tell Us about Their Functions in Biology?    

10:10 – 10:25 AM Coffee break - South atrium

Mitsuhiko Ikura, University of Toronto
Probing Cancer Cell Signaling by NMR: Structure, Interaction, and Enzymatic Kinetics of Small GTPases

Silvia Cavagnero, University of Wisconsin-Madison
NMR Sensitivity Enhancement by Laser-driven Approaches

Gaetano Montelione, Rutgers University
The Influenza Non-Structural Protein 1.  Biological Insights from Structural Studies

Slobodan Macura, Mayo Foundation
Study of 18O/16O Isotope Labeling Networks in Metabolic Oligo-phosphates by J-decoupled 31P NMR Chemical Shift Correlation Spectroscopy

12:05 – 1:30 PM Lunch - Explore the neighborhood

1:30 – 4:05 Afternoon session - Forum
Session Chair: John Markley

Heinz Ruterjans, University of Frankfurt
45 Years of Biological NMR

Robert Kaptein, Utrecht University
The Lac Repressor: Structure, Dynamics, and Allosteric Interactions

Masatsune Kainosho, Tokyo Metropolitan University
Perspectives of SAIL-related Methods for Studying Structures and Dynamics of Larger Proteins

2:45 – 3:00 Coffee break - South atrium

Gordon Roberts, University of Leicester
A Tale of Talin - Multiple Domains with Different Functions from the Same Fold

Oleg Jardetzky, Stanford University
Relaxation Theory and Protein Dynamics

4:05 – 6:00 Poster session - South atrium

6:30 –7:00 Cocktails

7:00 –Banquet - Forum

Tuesday, June 28th

8:00 – 8:30 AM Light breakfast - South atriu

8:30 AM – 12:05 PM Morning session - Forum
Session Chair: Samuel Butcher

Ad Bax, The National Institutes of Health
Motions of a Fusion Peptide in Lipid Bilayers from Size-Dispersed 15N NMR Relaxation

Angela Gronenborn, University of Pittsburgh School of Medicine
New Members of the CVNH Family and Other Anti-HIV Lectins

Hector Deluca, University of Wisconsin-Madison
The Vitamin D System:  A New NMR Mine

Tim Bugni, University of Wisconsin-Madison
Exploring the Secondary Metabolome of Marine Invertebrate Associated Bacteria

10:10 – 10:25 AM Coffee break - South atrium

Juli Feigon, University of California Los Angeles
The Architecture of Human Telomerase RNA

Samuel Butcher, University of Wisconsin-Madison
Structural Biology of U6 Spliceosomal RNA

Katherine Henzler-Wildman, Washington University in St. Louis
Direct Observation of Conformational Exchange in the Small Multidrug Resistance Transporter, EmrE

Jeffrey Hoch, University of Connecticut Health Center
Maximum Entropy Reconstruction of Nonuniformly Sampled Multidimensional NMR Data

12:05 – 1:30 PM Lunch - Explore the neighborhood

1:30 – 4:15 PM Afternoon session - Forum
Session Chair: William M. Westler

Brian Volkman, Medical College of Wisconsin
Access to the Unfolded State as a Functional Necessity in Intrinsically Folded Proteins

Mark Girvin, Albert Einstein College of Medicine
Bicelles and Peptide-lipid Diskettes for Integral and Membrane Associated Proteins

Andrew Hinck, The Univ. of Texas Health Center at San Antonio
Flexibility and Function in TGF-? Signal Transduction

2:45 – 3:00 PM Coffee break - South atrium

Art Edison, University of Florida
Nematode Chemical Ecology

Michael Reily, Bristol-Myers Squibb
Putting Metabolomics to Practice in Pharmaceutical R&D

Charles Hoogstraten, Michigan State University
Dynamics and Function in Catalytic RNA

4:15 – 4:30 PM Closing remarks: John L. Markley

4:30 – 6:00 PM Poster session - South atrium