Synthetic Genes to Synthetic Life

33rd Steenbock Symposium - Jul 30, 2009 to Aug 02, 2009


Thursday, July 30, 2009

4:00 - 5:45 pm - Reception and Registration - Pick up conference materials at Khorana Auditorium (Room 175 Biochemistry Addition, 433 Babcock Drive)

Session 1 - General

6:00pm - Welcome
Aseem Ansari, UW-Madison

6:05pm - 6:20pm - Comments
Chair: Uttam RajBhandary, MIT

6:20pm - 6:40pm Nucleic Acid Chemistry: From Gobind to the Present - Video
Marvin Caruthers, University of Colorado - Boulder

6:40pm - 7:00pm Viral Membrane Fusion and its Inhibition - Video
Peter Kim, Merck

7:00pm - 7:20pm The Metabolism and Function of Dehydroepiandrosterone - Video
Henry Lardy, UW-Madison

7:20pm - 7:40pm Deciphering the Genetic Code - Video
Marshall Nirenberg, National Institute of Health

7:40pm - 8:00pm Regulation of Tumor Metastasis by MAP Kinase and MicroRNAs
Marsha Rosner, University of Chicago

Friday, July 31, 2009

Session 2 - Nucleic Acids

8:30am - Continental Breakfast

9:00am - 9:05am - Comments
Chair: Hara Ghosh

​9:05am - 9:25am Non-B DNA Conformations, Mutagenesis and Disease - Video
Robert Wells, Texas A&M

9:25am - 9:45am Bisulfite Modification of Nucleotides: Mechanistic Consideration leading to improved Protocols of DNA Methylation Analysis - Video
Hikoya Hayatsu, Okayama University

9:45am - 10:05am The Puzzle of Prophage λ Stability - Video
Sankar Adhya, National Cancer Institute

10:05am - 10:25am The Genetic Code Revisited – Four Decades after Francis Crick - Video
Dieter Söll, Yale

10:25am - 10:45am - Coffee Break

10:45am - 10:50am - Comments
Chair: Takao Sekiya

​10:50am - 11:10am One RNA Aptamer Sequence, Two Structures: A Collaborating Pair that Competitively Inhibits AMPA Receptors - Video
Li Niu, University at Albany

11:10am - 11:30am The Hopeful Cornucopia - A study into Combinatorial Gene Synthesis - Video
Hans-Joachim Fritz, Georg-August-Univsitat

​11:30am - 11:50am Efficient Synthesis of Oligonucleotide Conjugates on Solid-Support Using an (Aminoethoxycarbonyl) aminohexyl Group for 5’-Terminal Modification - Video
Eiko Ohtsuka, AIST

​11:50am - 12:10pm The First Crystallographic Structure of Mammalian Phosphofructokinase from Rabbit Skeletal Muscle - Video
Simon Chang, LSU

12:10pm - 1:45pm - Lunch and Poster Session

Session 3 - Membranes, Receptors and Signaling

1:45pm - 1:50pm - Comments
Chair: Pere Garriga

1:50pm - 2:10pm Gobind Khorana and My Current Research on Drosophila Behavior - Video
Julius Adler, UW-Madison

2:10pm - 2:30pm Oxygen Control of Cyclic di-GMP Homeostasis - Video
Marie-Alda Gilles-Gonzalez, UT Southwestern

2:30pm - 2:50pm Gobind Khorana and the “Central Dogma” of Receptor Activation - Video
Wayne Hubbell, UCLA

2:50pm - 3:10pm Heptahelical Receptors: Ligand Recognition and Conformational Dynamics in Bilayers - Video
Thomas Sakmar, Rockefeller

3:10pm - 3:30pm Dynamics of G-Protein Coupled Receptor (GPCR) Activation and Attenuation: Insights from Fluorescence Studies - Video
David Farrens, Oregon Health & Science

3:30pm - 4:00pm - Break

4:00pm - 4:05pm - Comments
Chair: Umesh Varshney

​4:05pm - 4:25pm Pharmacogenetics of the Human Prostacyclin Receptor: “hIP, SNiP COX and Vioxx” - Video
John Hwa, Dartmouth

4:25pm - 4:45pm Signaling via Structure Change: NMR Analysis of GPCR and G protein Activation - Video
Kevin Ridge, University of Texas

4:45pm - 5:05pm Learning from Rhodopsin about Metabotropic Glutamate Receptors - Video
Judith Klein-Seetharaman, University of Pittsburgh

5:05pm - 5:25pm Oncogenic Kit Receptor Signaling and Targeted Molecular Therapies – in Mouse Models of Gastrointestinal Stromal Tumor - Video
Peter Besmer, Sloan-Kettering

6:00pm - 10:00pm - Madison Club Reception

Saturday, August 1, 2009

Session 4 - Genes and Regulation

8:00am - Continental Breakfast

8:25am - 8:30am - Comments
Co-Chairs: Molly Jahn & Masayasu Nomura

8:30am - 8:55am Binding Reactions: Epigenetic Switches, Signal Transduction, Evolution and Cancer - Video
Mark Ptashne, Sloan Kettering

8:55am - 9:20am Transcription Factors as Targets for Cancer Therapy - Video
Peter Dervan, Caltech

9:20am - 9:45am RNA as a Gene Regulation Modality - Video
Phillip Sharp, MIT

9:45am - 10:05am Dissecting the roles of X. laevis miRNAs and Ago proteins in RISC activity - Video
James Dahlberg, UW-Madison

10:05am - 10:30am Large Structured Non-coding RNAs Revealed by Bacterial Metagenome Analysis - Video
Ronald Breaker, Yale

10:30am - 10:45am - Coffee Break

Session 5 - Genomes, Networks, Systems and Molecular Medicine

10:45am - 10:50pm - Comments
Chair: Lloyd Smith

10:50am - 11:15am Systems Biology, Transforming Technologies and the Emergence of P4 Medicine (Predictive, Personalized, Preventive and Participatory) - Video
Lee Hood, Systems Biology

11:15am - 11:40am Programming Cell State - Video
Richard Young, Whitehead Institue - MIT

11:40am - 12:05pm The "Dark Matter" of Biological Regulation? - Video
Patrick Brown, Stanford

12:05pm - 12:25pm Acquired Stress Resistance in Yeast: Multiple Means to the Same End - Video
Audrey Gasch, UW-Madison

12:30pm - 2:30pm - Lunch and Poster Session (Continued)

Session 6 - Rewiring Cell Fate and Signaling Pathways

2:30pm - 2:35pm - Comments
Chair: Jennifer Reed

2:35pm - 2:55pm Human Induced Pluripotent Stem Cells Derived with Episomal Vectors - Video
James Thomson, UW-Madison

2:55pm - 3:20pm Biological Innovation: The Evolution and Engineering of New Signaling Systems - Video
Wendell Lim, UCSF

3:20pm - 3:40pm Chemical Probes of Receptor Assembly in Signaling - Video
Laura Kiessling, UW-Madison

Session 7 - Rewiring Genes and Networks (Biofuels)

3:40pm - 3:45pm - Comments
Chair: Tim Donohue

3:45pm - 4:10pm Synthetic Biology for Synthetic Fuels - Video
Jay Keasling, Berkley

4:10pm - 4:30pm Genome-scale Chromosomal Engineering of Bacterial Hosts for Bioenergy Production - Video
Robert Landick, UW-Madison

4:30pm - 4:45pm - Break

Session 8A - Origins and Designing Life - Synthetic Life

4:45pm - 4:50pm - Comments
Chair: Aseem Ansari

​4:50pm - 5:15pm Making a Synthetic Cell - Video
Hamilton Smith, J. Craig Venter Institute

5:15pm - 5:40pm Reading and Writing Genomes - Video
George Church, Harvard Medical

5:40pm - 6:05pm Questions about Questions about the Origin of Life - Video
George Whitesides, Harvard

6:05pm - 6:30pm Synthetic Biology in Ethical Perspective - Video
Alta Charo, UW-Madison

7:00pm - 9:00pm - Banquet (Pyle Center - Alumni Lounge, 702 Langdon Street)
Violin Concerto - Ptashne with Adrian Levine & Sara Sitzer
​Banquet speaker: William Dove

Sunday, August 2, 2009

Session 8B - Origins and Designing Life - Synthetic Genes and Genomes

8:00am - 8:25am - Continental Breakfast

8:25am - 8:30am - Comments & Synthetic multi-cullular systems biology - Video
Chair: Eric Werner

8:30am - 8:50am Reducing the genome of E. coli: a top down approach to synthetic biology - Video
Fredrich Blattner, UW-Madison

8:50am - 9:15am To Be Announced - Video
Thomas Knight, MIT

9:15am - 9:40am The Physics of Genome Management - Video
Rob Phillips, Caltech

​Session 9 - Nano-Devices and Biomachines

9:40am - 9:45am - Comments
Co-Chairs: Franco Cerrina & George Phillips

9:45am - 10:10am DNA: Not Merely the Secret of Life - Video
Nadrian Seeman, New York University

10:10am - 10:35am Programmable Self-assembly of DNA into Nanoscale Three-dimensional Shapes - Video
William Shih, Harvard Medical

10:35am - 10:55am Top Down Meets Bottom Up: Controlled Placement of DNA Nanostructures - Video
Ryan Kershner, UW-Madison

Session 10 - Development, Disease and Drug Design

10:55am - 11:00am - Comments
Co-Chairs: James Ntambi & Hasan Mukhtar

​11:00am - 11:25am Transcriptional Precision in the Drosophila Embryo - Video
Michael Levine, Berkeley

11:25am - 11:45am Gene Networks and Type 2 Diabetes - Video
Alan Attie, UW-Madison

11:45am - 12:05pm Direct Inhibition of the Notch Transactivation Complex - Video
James Bradner, Dana-Farber Cancer Institute

12:05pm - 12:25pm - Closing Remarks
Waclaw Szybalski, UW-Madison