The community of microorganisms that resides in the gut, known as the microbiome, has been shown to work in tandem with the genes of a host organism to regulate insulin secretion, a key variable in the onset of the metabolic disease diabetes.
That is the primary finding of a study published Feb. 14 in the journal Cell Reports by a team led by University of Wisconsin–Madison Alan Attie of the Department of Biochemistry and Federico Rey of the Department of Bacteriology. The new report describes experiments in mice showing how genetic variation in a host animal shapes the microbiome...
Technology is becoming more and more important for the study of biochemistry. Powerful computer programs can help researchers make three-dimensional models of molecules or analyze their data to create easy-to-understand plots. In the Department of Biochemistry, senior scientist Jean-Yves Sgro is bringing hands-on workshops to students, staff, and faculty so they can learn these valuable skills.
The Department of Biochemistry and the Department of Biomolecular Chemistry are pleased to invite you to register for the 38th Steenbock Symposium on June 22-June 25, 2017. The registration deadline is May 14, with the early registration deadline falling on March 30.
The symposium’s theme, “Protein Trafficking in the Secretory Pathway,” will bring together researchers from the United States, as well as from Europe and Canada, to discuss and explore this important biochemical pathway. The symposium will take place on campus in the Wisconsin Institutes for Discovery Building.
Human messenger RNA — the intermediate step between DNA and protein — is a bit like a choose-your-own-adventure book. Any book contains chapters arranged to tell a story. However, in a choose-your-own adventure, random chapters can be removed and the remaining sections stitched together in different combinations — and all of these new combinations tell a new story.
Ronald Raines, the Henry Lardy Professor of Biochemistry, earned two national awards over the holiday. He was elected as a Fellow of the National Academy of Inventors (NAI) and also received the Vincent du Vigneaud Award from the American Peptide Society (APS).
Science students, like those majoring in biochemistry, aren’t just tucked away in research labs. They also participate in making their college a better and more welcoming place for current and potential students. Gina Luu and Ryan Rebernick, both biochemistry undergraduates, are serving as College of Agricultural and Life Sciences (CALS) Ambassadors for the 2016-17 academic year.
CALS Ambassadors serve as a bridge between current students and incoming and prospective students. They serve as CALS-focused tour guides for interested students coming to check out the college. They also...
Researchers at the University of Wisconsin–Madison have developed a novel strategy to reprogram cells from one type to another in a more efficient and less biased manner than previous methods.
The ability to convert cells from one type to another holds great promise for engineering cells and tissues for therapeutic application, and the new Wisconsin study could help speed research and bring the technology to the clinic faster.
With at least 20 articles published in the journal in the last five years, biochemistry professor Hazel Holden was named a selected highly prolific author by the journal Biochemistry. To mark the publication of the one-millionth article in its many journals, the American Chemical Society, which runs Biochemistry, has honored researchers in different categories.
The Holden Laboratory studies the structures and functions of enzymes involved in unusual sugar biosynthesis. These types of sugars are found, for example, on antibiotics, antifungals, and antitumor agents.
Professor of Biochemistry Ann Palmenberg, known for her work in molecular virology, has been elected a 2016 Fellow of the American Association for the Advancement of Science (AAAS). She is one of five faculty from the University of Wisconsin–Madison named a Fellow this year.
Election as a AAAS Fellow, a tradition begun in 1874, is recognition by peers for distinguished contributions to advance science or its applications.
“It is indeed an honor to be elected as a Fellow of such an illustrious Academy,” says Palmenberg, who is also part of the Institute for Molecular Virology...
Biochemists at the University of Wisconsin–Madison have created the first atlas that maps where molecular tools that can switch genes on and off will bind to the human genome. It is a development they say could enable these tools to be targeted to specific parts of an individual’s genome for use in precision medicine, developing therapies and treating disease.
The study is published this week (Monday, Nov. 7) in the Proceedings of the National Academy of Sciences. The tools are polyamides, engineered DNA-binding molecules that are an important component of artificial transcription...
Extracting DNA from wheat germ and talking about the science of sugar — just a few ways students in the Department of Biochemistry embody the Wisconsin Idea by participating in science outreach. Biochemistry undergraduates and graduate students from the Integrated Program in Biochemistry (IPiB) took part in activities at the Wisconsin Science Festival on Oct. 20-23.
How much of your DNA comes from ancient humans? Where do you think humans originated and how did we spread across the globe? The Department of Biochemistry at the University of Wisconsin–Madison invites you to a campus-only talk on Thursday, Dec. 8 and a public talk Friday, Dec. 9 by esteemed researcher Svante Pääbo to explore his answers to these questions.
Pääbo, of the Max Planck Institute for Evolutionary Anthropology in Germany, is known as one of the founders of paleogenetics, which is the study of ancient DNA and genetics to understand the past. He specializes in retrieving...
When scientists reported in 2014 that they had successfully engineered a poplar plant “designed for deconstruction,” the finding made international news. The highly degradable poplar, the first of its kind, could substantially reduce the energy use and cost of converting biomass to a number of products, including biofuels, pulp, and paper.
Now, more than two years later, some of those same researchers are reporting a surprising new revelation. As University of Wisconsin–Madison professor of biochemistry John Ralph puts it, “Nature was already doing what we thought we’d laboriously...
Proteins are the hammers and tongs of life, with fundamental roles in most of what happens in biology. But biologists still don’t know what thousands of proteins do, and how their presence or absence affects the cell.
The intellectual black hole extends to mitochondria, the cells’ energy machines, which falter in more than 150 diseases, including cancer, diabetes, Parkinson’s and numerous genetic disorders.
To fill in the blanks on mitochondria, researchers at the University of Wisconsin–Madison deleted 174 genes, one by one, in yeast. They then subjected the yeast to high-...
Biochemistry undergraduates have a new and improved student organization to join this year, as the Undergraduate Biochemistry Student Organization (UBSO) has morphed into a student chapter of the American Society for Biochemistry and Molecular Biology (ASBMB).
The organization’s first meeting will be at 6 p.m. on Thursday, Sept. 22 in Room 1116 of the Hector F. DeLuca Biochemistry Building (420 Henry Mall). The UW–Madison Chapter of ASBMB will give students numerous resources, such as career path exploration and peer-to-peer networking. Sam Tesch, the president of the student...