Kiessling Lab Logo



Wesener DA, Wangkanont K, McBride R, Song X, Kraft MB, Hodges HL, Zarling LC, Splain RA, Smith DF, Cummings RD, Paulson JC, Forest KT, Kiessling LL. Recognition of microbial glycans by human intelectin-1. Nat Struct Mol Biol. 2015 Aug;22(8):603-10. [PDF]

Bennett NR, Zwick DB, Courtney AH, Kiessling LL. Multivalent Antigens for Promoting B and T Cell Activation. ACS Chem Biol. 2015 Aug 21;10(8):1817-24. [PDF]

Kincaid VA, London N, Wangkanont K, Wesener DA, Marcus SA, Héroux A, Nedyalkova L, Talaat AM, Forest KT, Shoichet BK, Kiessling LL. Virtual Screening for UDP-Galactopyranose Mutase Ligands Identifies a New Class of Antimycobacterial Agents. ACS Chem Biol. 2015 Aug 17. [Epub ahead of print] [PDF]

Wangkanont K, Forest KT, Kiessling LL. The non-detergent sulfobetaine-201 acts as a pharmacological chaperone to promote folding and crystallization of the type II TGF-β receptor extracellular domain. Protein Expr Purif. 2015 Jun 11. pii: S1046-5928(15)00140-0. [PDF]

Wrighton PJ, Kiessling LL. Forces of Change: Mechanics Underlying Formation of Functional 3D Organ Buds. Cell Stem Cell. 2015 May 7;16(5):453-4. [PDF]


Wrighton PJ, Klim JR, Hernandez BA, Koonce CH, Kamp TJ, Kiessling LL. Signals from the surface modulate differentiation of human pluripotent stem cells through glycosaminoglycans and integrins. Proc Natl Acad Sci U S A. 2014 Dec 23;111(51):18126-31. [PDF]

Guo LT, Wang YS, Nakamura A, Eiler D, Kavran JM, Wong M, Kiessling LL, Steitz TA, O'Donoghue P, Söll D. Polyspecific pyrrolysyl-tRNA synthetases from directed evolution. Proc Natl Acad Sci U S A. 2014 Nov 25;111(47):16724-9. [PDF]

Musah S, Wrighton PJ, Zaltsman Y, Zhong X, Zorn S, Parlato MB, Hsiao C, Palecek SP, Chang Q, Murphy WL, Kiessling LL. Substratum-induced differentiation of human pluripotent stem cells reveals the coactivator YAP is a potent regulator of neuronal specification. Proc Natl Acad Sci U S A. 2014 Sep 23;111(38):13805-10. [PDF]

Sheridan RT, Hudon J, Hank JA, Sondel PM, Kiessling LL. Rhamnose glycoconjugates for the recruitment of endogenous anti-carbohydrate antibodies to tumor cells. Chembiochem. 2014 Jul 7;15(10):1393-8. [PDF]

Martinez Farias MA, Kincaid VA, Annamalai VR, Kiessling LL. Isoprenoid phosphonophosphates as glycosyltransferase acceptor substrates. J Am Chem Soc. 2014 Jun 18;136(24):8492-5. [PDF]

Briegel A, Wong ML, Hodges HL, Oikonomou CM, Piasta KN, Harris MJ, Fowler DJ, Thompson LK, Falke JJ, Kiessling LL, Jensen GJ. New insights into bacterial chemoreceptor array structure and assembly from electron cryotomography. Biochemistry. 2014 Mar 18;53(10):1575-85. [PDF]

Courtney AH, Bennett NR, Zwick DB, Hudon J, Kiessling LL. Synthetic antigens reveal dynamics of BCR endocytosis during inhibitory signaling. ACS Chem Biol. 2014 Jan 17;9(1):202-10. [PDF]


Kiessling LL, Kraft MB. Chemistry. A path to complex carbohydrates. Science. 2013 Jul 26;341(6144):357-8. [PDF]

Wesener DA, May JF, Huffman EM, Kiessling LL. UDP-Galactopyranose Mutase in Nematodes; Biochemistry. 2013 Jun 25;52(25):4391-8. [PDF]

Kiessling LL, Grim JC. Glycopolymer probes of signal transduction. Chem Soc Rev. 2013 May 21;42(10):4476-91. [PDF]

Fishman JM, Kiessling LL. Synthesis of functionalizable and degradable polymers by ring-opening metathesis polymerization.;Angew Chem Int Ed Engl. 2013 May 3;52(19):5061-4. [PDF]

Kraft MB, Martinez Farias MA, Kiessling LL. Synthesis of lipid-linked arabinofuranose donors for glycosyltransferases.J Org Chem. 2013 Mar 1;78(5):2128-33. [PDF]


Musah S, Morin SA, Wrighton PJ, Zwick DB, Jin S, Kiessling LL. Glycosaminoglycan-binding hydrogels enable mechanical control of human pluripotent stem cell self-renewal. ACS Nano. 2012 Nov 27;6(11):10168-77. [PDF]

Kiessling LL. Recasting Biomolecules for Function. ACS Chem Biol. 2012 Jan 20;7(1):1-2. [PDF]

Prost LR, Grim JS, Tonelli M, Kiessling LL. Non-Carbohydrate Glycomimetics and Glycoprotein Surrogates as DC-SIGN Antagonists and Agonists. ACS Chem Biol. 2012 Jul 19 [PDF]

Brown CD, Rusek MS, Kiessling LL. Fluorosugar chain termination agents as probes of the sequence specificity of a carbohydrate polymerase. J Am Chem Soc. 2012 Apr 18;134(15):6552-5. Epub 2012 Apr 10. [PDF]

Mangold SL, Prost LR, Kiessling LL. Quinoxalinone Inhibitors of the Lectin DC-SIGN. Chem Sci. 2012 Mar;3(3):772-777. Epub 2011 Nov. 24. [PDF]

Wong ML, Guzei IA, Kiessling LL. An Asymmetric Synthesis of l-Pyrrolysine. . 2012 Mar 16;14(6):1378-81. Epub 2012 Mar 6. [PDF]

May JF, Levengood MR, Splain RA, Brown CD, Kiessling LL. A processive carbohydrate polymerase that mediates bifunctional catalysis using a single active site. Biochemistry. 2012 Feb 14;51(6):1148-59. Epub 2012 Feb 3. [PDF]

Klim JR, Fowler AJ, Courtney AH, Wrighton PJ, Sheridan RT, Wong ML, Kiessling LL. Small-Molecule-Modified Surfaces Engage Cells through the α(v)β(3) Integrin. ACS Chem Biol. 2012 Mar 16;7(3):518-25. Epub 2012 Jan 26. [PDF]


Levengood MR, Splain RA, Kiessling LL. Monitoring Processivity and Length Control of a Carbohydrate Polymerase. J Am Chem Soc. 2011 Jul 25 Epub. [PDF]

Li L, Klim JR, Derda R, Courtney AH, Kiessling LL (2011) Spatial control of cell fate using synthetic surfaces to potentiate TGF-B signaling. Proc Natl Acad Sci USA. 108(29):11745-50. Epub 2011 Jun 30 [PDF]

Grim JC, Garber KC, Kiessling LL (2011) Glycomimetic Building Blocks: A Divergent Synthesis of Epimers of Shikimic Acid. Org. Lett. 2011 Jun 28 Epub [PDF]

Underbakke ES, Zhu Y, Kiessling LL (2011) Protein Footprinting in a Comples Milieu: Identifying the Interaction Surfaces of the Chemotaxis Adaptor Protein CheW. J Mol Biol.409(4):483-95 [PDF]


Klim JR, Li L, Wrighton PJ, Piekarczyk MS, Kiessling LL (2010) A defined glycosaminoglycan-binding substratum for human pluripotent stem cells. Nat Methods. 7(12):989-94 [PDF]

Underbakke ES, Kiessling LL (2010) Classifying chemoreceptors: quantity versus quality. EMBO J. 29(20):3435-6 [PDF]

Li L, Orner BP, Huang T, Hinck AP, Kiessling LL (2010) Peptide ligands that use a novel site to target both TGF-beta receptors. Mol Biosyst. 6(12):2392-402 [PDF]

Garber KC, Wangkanont K, Carlson EE, Kiessling LL (2010) A general glycomimetic strategy yields non-carbohydrate inhibitors of DC-SIGN. Chem Commun (Camb). 46(36):6747-9 [PDF]

Jiarpinitnum C, Kiessling LL (2010) Unexpected enhancement in biological activity of a GPCR ligand induced by a n oligoethylene glycol substitute. J Am Chem Soc. 132(26):8844-5 [PDF]

Splain RA, Kiessling LL (2010) Synthesis of galactofuranose-based acceptor substrates for the study of the carbohydrate polymerase GlfT2. Bioorg Med Chem. 18(11):3753-9 [PDF]

Kiessling LL, Splain RA (2010) Chemical approaches to glycobiology. Annu Rev Biochem 79:619-53 [PDF]

Kiessling LL. (2010) Decoding signals with chemical biology. ACS Chem Biol. 5(1):1-2 [PDF]

Derda R, Musah S, Orner BP, Klim JR, Li L, Kiessling LL. (2010) High-throughput discovery of synthetic surfaces that support proliferation of pluripotent cells. J Am Chem Soc. 132(4):1289-95 [PDF]


Gruber TD, Westler WM, Kiessling LL, Forest KT (2009) X-ray crystallography reveals a reduced substrate complex of UDP-galactopyranose mutase poised for covalent catalysis by flavin. Biochemistry. 48(39):9171-3 [PDF]

Lamanna AC, Kiessling LL (2009) Flow cytometry reveals that multivalent chemoattractants effect swarmer cell dedifferentiation. ACS Chem Biol. 4(10):828-33 [PDF]

May JF, Kiessling LL (2009) A tethering mechanism for length control in a processive carbohydrate polymerization. Proc Natl Acad Sci USA 106(29):11851-11856 [PDF]

Gruber TD, Borrok MJ, Westler WM, Forest KT, Kiessling LL. (2009) Ligand binding and substrate discrimination by UDP-Galactopyranose mutase. J Mol Biol. 391(2):327-340 [PDF]

Kolonko EM, Pontrello JK, Mangold SL, Kiessling LL. (2009) General synthetic route to cell-permeable block copolymers via ROMP. J Am Chem Soc. 131(21):7327-7333 [PDF]

Dykhuizen EC, Kiessling LL. (2009) Potent ligands for prokaryotic UDP-galactopyranose mutase that exploit an enzyme subsite. Org Lett. 11(1):193-196 [PDF]

Courtney AH, Puffer EB, Pontrello JK, Yang ZQ Kiessling LL. (2009) Sialylated multivalent antigens engage CD22 in trans and inhibit B cell activation. Proc Natl Acad Sci USA 106(8):2500-2505 [PDF]

Borrok MJ, Zhu Y, Forest KT, Kiessling LL. (2009) Structure-based design of a periplasmic binding protein antagonist that prevents domain closure. ACS Chem Biol. 4(6):447-456 [PDF]

Allen MJ, Wangkanont K, Raines RT, Kiessling, LL. (2009) ROMP from ROMP: A new approach to graft copolymer synthesis. Macromolecules. 42(12):4023-4027 [PDF]


Underbakke ES, Zhu Y, Kiessling LL. (2008) Isotope-coded affinity tags with tunable reactivities for protein footprinting. Angew Chem, Int Ed. 47(50):9677-9680 [PDF]

Mangold SL, Carpenter RT, Kiessling LL. (2008) Synthesis of fluorogenic polymers for visualizing cellular internalization. Org Lett. 10(14):2997-3000. PMID: 18563907 [PDF]

Dykhuizen EC, May JF, Tongpenyai A, Kiessling LL. (2008) Inhibitors of UDP-galactopyranose mutase thwart mycobacterial growth. J Am Chem Soc. 130(21):6706-7. PMID: 18447352 [PDF]

Kolonko EM, Kiessling LL. (2008) A polymeric domain that promotes cellular internalization.
J Am Chem Soc. 130(17):5626-7. PMID: 18393495 [PDF]

Borrok MJ, Kolonko EM, Kiessling LL. (2008) Chemical probes of bacterial signal transduction reveal that repellents stabilize and attractants destabilize the chemoreceptor array.
ACS Chem Biol. 3(2):101-9. PMID: 18278851 [PDF]


Borrok MJ, Kiessling LL. (2007) Non-carbohydrate inhibitors of the lectin DC-SIGN.
J Am Chem Soc. 129(42):12780-5. PMID: 17902657 [PDF]

Derda R, Wherritt DJ, Kiessling LL. (2007) Solid-phase synthesis of alkanethiols for the preparation of self-assembled monolayers. Langmuir. 23(22):11164-7. PMID: 17880250 [PDF]

Chad JM, Sarathy KP, Gruber TD, Addala E, Kiessling LL, Sanders DA.(2007) Site-directed mutagenesis of UDP-galactopyranose mutase reveals a critical role for the active-site, conserved arginine residues. Biochemistry. 46(23):6723-32. PMID: 17511471 [PDF]

Borrok MJ, Kiessling LL, Forest KT. (2007) Conformational changes of glucose/galactose-binding protein illuminated by open, unliganded, and ultra-high-resolution ligand-bound structures.
Protein Sci. 16(6):1032-41. PMID: 17473016 [PDF]

Derda R, Li L, Orner BP, Lewis RL, Thomson JA, Kiessling LL. (2007) Defined substrates for human embryonic stem cell growth identified from surface arrays. ACS Chem Biol. 2(5):347-55. PMID: 17480050 [PDF]

Kiessling LL, Doudna JA, Johnsson K, Mapp AK, Marletta MA, Seeberger PH, Williamson JR, Wedde SG. (2007) A higher degree of difficulty. ACS Chem Biol. 2(4):197-9. No abstract available. PMID: 17455890 [PDF]

Puffer EB, Pontrello JK, Hollenbeck JJ, Kink JA, Kiessling LL. (2007) Activating B cell signaling with defined multivalent ligands. ACS Chem Biol. 2(4):252-62. PMID: 17432821 [PDF]

Carlson CB, Mowery P, Owen RM, Dykhuizen EC, Kiessling LL. (2007) Selective tumor cell targeting using low-affinity, multivalent interactions. ACS Chem Biol. 2(2):119-27. PMID: 17291050 [PDF]

Owen, R.M., Carlson, C.B., Xu, J., Mowery, P., Fasella, E., and Kiessling, L.L. (2007) Bifunctional Ligands that Target Cells Displaying the ?v?3 Integrin, ChemBioChem, 8, 68 82. [PDF]

Carlson, C.B., Mowery, P., Owen, R.M., Dykhuizen, E,C,. and Kiessling, L.L (2007) Selective Tumor Cell Targeting Using Low-Affinity, Multivalent Interactions, ACS Chemical Biology, Vol.2 No. 2, 119. [PDF]


Kiessling, L.L., Wedde, S.G., and Ronald T. Raines (2006) Symbiosis: Chemical Biology at Wisconsin, ACS Chemical Biology, Vol.1 No. 8, 481. [PDF]

Kiessling, L.L., Gestwicki, J.E. and Strong, L.E. (2006) Synthetic Multivalent Ligands as Probes of Signal Transduction, Angew. Chem. Int. Ed., 45, 2348 2368. [PDF]

Orner B. P., Liu L., Murphy R.M., and Kiessling L.L. (2006) Phage Display Affords Peptides that Modulate ?-Amyloid Aggregation, J. Am. Chem. Soc., 128, 11882-11889. [PDF]

Carlson, E. E., May, J. F., and Kiessling, L. L. (2006) Chemical probes of UDP-galactopyranose mutase, Chem Biol. 13, 825-837. [PDF]

Kiessling, L. L. (2006) Fostering major breakthroughs, ACS Chem. Biol. 1, 1-2. [PDF]

He, Y., Wilkins, J. P., and Kiessling, L. L. (2006) N-acylsulfonamide linker activation by Pd-catalyzed allylation, Org. Lett. 8, 2483-2485. [PDF]

Allen, M. J., Raines, R. T., and Kiessling, L. L. (2006) Contrast agents for magnetic resonance imaging synthesized with ring-opening metathesis polymerization, J. Am. Chem. Soc. 128, 6534-6535. [PDF]


Pontrello, J.K., Allen, M.J., Underbakke, E,S, and Kiessling, L.L. (2005) Solid-Phase Synthesis of Polymers Using the Ring-Opening Metathesis Polymerization, J. Am. Chem. Soc., 127, 14536-14537. [PDF]

Borrok, D., Borrok, M. J., Fein, J. B., and Kiessling, L. L. (2005) Link between chemotactic response to Ni2+ and its adsorption onto the Escherichia coli cell surface, Environ. Sci. Technol. 39, 5227-5233. [PDF]

Lamanna, A. C., Ordal, G. W., and Kiessling, L. L. (2005) Large increases in attractant concentration disrupt the polar localization of bacterial chemoreceptors, Mol. Microbiol. 57, 774-785. [PDF]

Soltero-Higgin, M., Carlson, E.E., Phillips, J.H. and Kiessling, L.L. (2005) Identification of Inhibitors for UDP-Galactopyranose Mutase, J. Am. Chem. Soc., 126, 10532-10533. [PDF]


He, Y., Hinklin, R.J., Chang, J. and Kiessling, L.L. (2004) Stereoselective N-Glycosylation by Staudinger Ligation, Organic Letters, Vol. 6, No. 24, 4479-4482. [PDF]

Orner, B.P., Derda, R., Lewis, R.L., Thomson, J.A., and Kiessling, L.L. (2004) Arrays for the Combinatorial Exploration of Cell Adhesion, J. Am. Chem. Soc., 126, 10808-10809. [PDF]

Soltero-Higgin, M. L., Carlson, E. E., Gruber, T. D., and Kiessling, L. L. (2004) A unique catalytic mechanism for UDP-galactopyranose mutase, Nature Mol.Struct. Biol. 11, 539-543. [PDF]

Mowery, P., Yang, Z. Q., Gordon, E. J., Dwir, O., Spencer, A. G., Alon, R., and Kiessling, L. L. (2004) Synthetic glycoprotein mimics inhibit L-selectin-mediated rolling and promote L-selectin shedding, Chem. Biol. 11, 725-732. [PDF]

Carlson, E. E. and Kiessling, L. L. (2004) Improved chemical synthesis of 1- and 5-Deazariboflavin, J. Org. Chem. 69, 2614-2617. [PDF]

Griffith, B. R., Allen, B. L., Rapraeger, A. C., and Kiessling, L. L. (2004) A polymer scaffold for protein oligomerization, J. Am. Chem. Soc. 126, 1608-1609. [PDF]


Smith, E. A., Thomas, W. D., Kiessling, L. L., and Corn, R. M. (2003) Surface plasmon resonance imaging studies of protein carbohydrate interactions, J. Am. Chem. Soc. 125, 6140-6148. [PDF]

Schuster, M. C., Mann, D. A., Buchholtz, T. J., Johnson, K. M., and Kiessling, L. L. (2003) Parallel synthesis of glycomimetic libraries that target a C-type lectin, Org. Lett. 5 , 1407-1410. [PDF]

Genbacev, O. D., Prakobphol, A., Foulk, R. A., Krtolica, A. R., Ilic, D., Singer, M. S., Kiessling, L. L., Yang, Z. Q., Rosen, S. D., and Fisher, S. J. (2003) Trophoblast L-selectin mediates adhesive interactions at the human maternal fetal interface, Science 299, 405-408. [PDF]


Gestwicki, J. E., Cairo, C. W., Strong, L. E., Oetjen, K. A., and Kiessling, L. L. (2002) Influencing receptor ligand binding mechanisms with multivalent ligand architecture, J. Am. Chem. Soc. 124, 14922-14933. [PDF]

Yang, Z. Q., Puffer, E. B., Pontrello, J. K., and Kiessling, L. L. (2002) Synthesis of a multivalent display of a CD22-binding trisaccharide, Carbohydrate Res. 337, 1605-1613. [PDF]

Young, T. and Kiessling, L. L. (2002) A strategy for the synthesis of sulfated peptides, Angew. Chem. Int. Ed. Eng. 41, 3449-3451. [PDF]

Lamanna, A. C., Gestwicki, J. E., Strong, L. E., Borchardt, S. L., Owen, R. M., and Kiessling, L. L. (2002) Conserved amplification of chemotactic responses through chemoreceptor interactions, J. Bacteriol. 184, 4981-4987. [PDF]

Cairo, C. W., Strzelec, A., Murphy, R. M., and Kiessling, L. L. (2002) Affinity-based inhibition of ?-amyloid toxicity, Biochemistry 41, 8620-8629. [PDF]

Owen, R. W., Gestwicki, J. E., Young, T., and Kiessling, L. L. (2002) Synthesis and applications of end-labeled neoglycopolymers, Org. Lett. 4, 2293-2296. [PDF]

Gestwicki, J. E., Cairo, C. W., Mann, D. A., Owen, R. M., and Kiessling, L. L. (2002) Selective immobilization of multivalent ligands for surface plasmon resonance and fluorescence microscopy, Anal. Biochem. 305, 149-155. [PDF]

Gestwicki, J. E., Strong, L. E., Cairo, C. W., Boehm, F. J., and Kiessling, L. L. (2002) Cell aggregation by scaffolded receptor clusters, Chem. Biol. 9, 163-169. [PDF]

Cairo, C. W., Gestwicki, J. E., Kanai, M., and Kiessling, L. L. (2002) Control of multivalent interactions by binding epitope density, J. Am. Chem. Soc. 124, 1615-1619. [PDF]

Kiessling, L. L. and Cairo, C. W. (2002) Hitting the sweet spot, Nature Biotech. 20, 234-235. [PDF]

Gestwicki, J. E. and Kiessling, L. L. (2002) Inter-receptor communication through arrays of bacterial chemoreceptors, Nature 415, 81-84. [PDF]

Hinklin, R. J. and Kiessling, L. L. (2002) Para-methoxybenzyl ether cleavage by polymer-supported sulfonamides, Org. Lett. 4, 1131-1133. [PDF]


Gestwicki, J. E., Strong, L. E., Borchardt, S. L., Cairo, C. W., Schnoes, A. M., and Kiessling, L. L. (2001) Designed potent multivalent chemoattractants for Escherichia coli, Bioorg. Med. Chem. 9, 2387-2393. [PDF]

Marlow, A. L. and Kiessling, L. L. (2001) Improved chemical synthesis of UDP-galactofuranose, Org. Lett. 3, 2517-2519. [PDF]

Lowe, T. L., Strzelec, A., Kiessling, L. L., and Murphy, R. M. (2001) Structure-function relationships for Inhibitors of b-amyloid toxicity containing the recognition sequence KLFVV, Biochemistry 40, 7882-7889. [PDF]

Hinklin, R. J. and Kiessling, L. L. (2001) Glycosyl sulfonylcarbamates: New glycosyl donors with tunable reactivity, J. Am. Chem. Soc. 123, 3379-80. [PDF]

Nilsson, B. L., Kiessling, L. L., and Raines, R. T. (2001) High-yielding Staudinger ligation of a phosphinothioester and azide to form a peptide, Org. Lett. 3, 9-12. [PDF]

Bertozzi, C. R. and Kiessling, L. L. (2001) Chemical glyobiology, Science 291, 2357-2364. [PDF]

Kiessling, L. L. (2001) The Periodic Table, Chem. Eng. News 79, 246.

Steinmann, J. G., Phillips, J. H., Sanders, W. J., and Kiessling, L. L. (2001) Synthesis of cyclic sulfates by halocyclization, Org. Lett. 3, 3557-3559. [PDF]


Gestwicki, J. E., Strong, L. E., and Kiessling, L. L. (2000) Visualization of single multivalent receptor-liggand complexes by transmission electron microscopy, Angew. Chem. Int. Ed. Eng. 39, 4567-4570. [PDF]

Gestwicki, J. E., Lamanna, A. C., Harshey, R. M., McCarter, L. L., Kiessling, L. L., and Adler, J. (2000) Evolutionary conservation of methyl-accepting chemotaxis protein location in bacteria and archea, J. Bacteriol. 182, 6499-6502. [PDF]

Gestwicki, J. E., Strong, L. E., and Kiessling, L. L. (2000) Tuning chemotactic responses with synthetic multivalent ligands, Chem. Biol. 7, 583-591. [PDF]

Nilsson, B. L., Kiessling, L. L, and Raines, R. T. (2000). Staudinger ligation: A peptide from a thioester and azide, Org. Lett. 2, 1939-1941. [PDF]

Maki, N., Gestwicki, J. E., Lake, E. M., Kiessling, L. L. and Adler, J. (2000) Motility and chemotaxis of filamentous cells of Escherichia coli, J. Bacteriol. 182, 4337-4342. [PDF]

Burke, S. D., Zhao, Q., Schuster, M. C., and Kiessling, L. L. (2000) Synergistic formation of soluble lectin clusters by a templated multivalent saccharide ligand, J. Am. Chem. Soc. 122, 4518-4519. [PDF]

Gordon, E. J., Gestwicki, J. E., Strong, L. E., and Kiessling, L. L. (2000) Synthesis of end-labeled multivalent ligands for exploring cell surface receptor ligand interactions, Chem. Biol. 7, 9-16. [PDF]

Kiessling, L. L., Gestwicki, J. E., and Strong, L. E. (2000) Synthetic multivalent ligands in the exploration of cell surface interactions, Curr. Opin. Chem. Biol. 4, 696-703. [PDF]

Kiessling, L. L, Strong, L. E., and Gestwicki, J. E. (2000) Principles for multivalent ligand design. Annu. Reports Med. Chem 35, 321-330. [PDF]


Pohl, N. L. and Kiessling, L. L. (1999) Scope of multivalent ligand function: Lactose-bearing neoglycopolymers by ring-opening metathesis polymerization, Synthesis SI, 1515-1519. [PDF]

Strong, L. E. and Kiessling, L. L. (1999) A general synthetic route to defined, biologically active multivalent arrays, J. Am. Chem. Soc. 121, 6193-6196. [PDF]

Pallitto, M. M., Ghanta, J., Heinzelman, P., Kiessling, L. L., and Murphy, R. M. (1999) Recognition sequence design for peptidyl modulators of b-amyloid aggregation and toxicity, Biochemistry 38, 3570-3578. [PDF]

Sanders, W. J., Gordon, E. J., Dwir, O., Beck, P. J., Alon, R. T., and Kiessling, L. L. (1999) Inhibition of L-selectin-mediated leukocyte rolling by synthetic glycoprotein mimics, J. Biol. Chem. 274, 5271-5278. [PDF]

Kiessling, L. L., DeGrado, W. F., and Ecstein, F. (1999) Modulation of nucleic acids, carbohydrates and proteins to different task, Curr. Opin. Chem. Biol. 3(6), 641-642. [PDF]


Mann, D. A., Kanai, M., Maly, D. J., and Kiessling, L. L. (1998) Probing low affinity and multivalent interactions with surface plasmon resonance: Ligands for Concanavalin A, J. Am. Chem. Soc. 120, 10375-10383. [PDF]

Gordon, E. J., Strong, L. E., and Kiessling, L. L. (1998) Glycoprotein-inspired materials promote the proteolytic release of cell surface L-selectin, Bioorg. Med. Chem. 6, 1293-1299. [PDF]

Gordon, E. J., Sanders, W. J., and Kiessling, L. L. (1998) Synthetic ligands point to cell surface strategies, Nature 392, 30-31. [PDF]

Kiessling, L. L. and Gordon, E. J. (1998) Transforming the extracellular environment through proteolysis, Chemistry & Biology 5, R49-62. [PDF]


Sanders, W. J., Manning, D. D., Koeller, K., and Kiessling, L. L. (1997) Synthesis of sulfated trisaccharide ligands for the selectins, Tetrahedron Symposium in Print: Synthetic Methods 53, 16391-16422. [PDF]

Kanai, M., Mortell, K. H., and Kiessling, L. L. (1997) Varying the size of multivalent ligands: The dependence of Concanavalin A inhibition on neoglycopolymer length, J. Am. Chem. Soc. 119, 9931-9932. [PDF]

Pohl, N. L. and Kiessling, L. L. (1997) Para-chloro benzyl groups as stabilizers of the glycosidic linkage, Tetrahedron Lett. 38, 6985-6988. [PDF]

Manning, D. D., Strong, L. E., Hu, X., Beck, P. J., and Kiessling, L. L. (1997) Neoglycopolymer inhibitors of the selectins, Tetrahedron Symposium in Print: Bioorg. Chem. 53, 11937-11952.

Manning, D. D., Hu, X., Beck, P. J., and Kiessling, L. L. (1997) Synthesis of sulfated neogly-copolymers: Selective P-selectin inhibitors, J. Am. Chem. Soc. 119, 3161-3162. [PDF]

Kurutz, J. K. and Kiessling, L. L. (1997) Solution conformation of Lewis a-derived selectin ligands is unaffected by anionic substituents at the 3'- and 6'-positions, Glycobiol. 7, 337-347. [PDF]

Hegg, E., Deal, K., Kiessling, L. L, and Burstyn, J. N. (1997) Hydrolysis of double-stranded and single-stranded RNA in hairpin structures by the copper (II) macrocycle Cu([9]aneN3)Cl2, Inorg. Chem. 36, 1715-1718. [PDF]

Schuster, M. C., Mortell, K. H., Hegeman, A. D., and Kiessling, L. L. (1997) Neoglycopolymers produced by ring-opening metathesis polymerization: Decreasing saccharide density increases activity, J. Mol. Cat. A: Chemical 116, 209-216. [PDF]


Schueller, C. M., Manning, D. D., and Kiessling, L. L. (1996) Preparation of R-(+)-7-oxabicyclo[2.2.1]hept-5-ene-exo-2-carboxylic acid, a precursor to substrates for the ring opening metathesis polymerization, Tetrahedron Lett. 37, 8853-8856. [PDF]

Dantzman, C. L. and Kiessling, L. L. (1996) Reactivity of a 2' thio nucleotide analog, J. Am. Chem. Soc. 118, 11715-11719. [PDF]

Ghanta, J., Shen, C.-L., Kiessling, L. L., and Murphy, R.M. (1996) A strategy for designing inhibitors of ?-amyloid toxicity, J. Biol. Chem. 271, 29525-29528. [PDF]

Sanders, W. J., Katsumoto, T. R., Bertozzi, C. R., Rosen, S. D., and Kiessling, L. L. (1996) L-selectin carbohydrate onteractions: Relevant modifications of the Lewis x trisaccharide, Biochemistry 35, 14862-14867. [PDF]

Brüning, J. and Kiessling, L. L. (1996) Convergent synthesis of sulfated bivalent glycopeptides as selectin ligands, Tetrahedron Lett. 37, 2907-2910. [PDF]

Manning, D. D., Bertozzi, C. R., Rosen, S. D., and Kiessling, L. L. (1996) Tin-mediated phosphorylation: Synthesis and selectin binding of a phospho Lewis a analog, Tetrahedron Lett. 37, 1953-1956. [PDF]

Mortell, K. H., Weatherman, R. V., and Kiessling, L. L. (1996) Recognition specificity of neoglycopolymers prepared by ring-opening metathesis polymerization, J. Am. Chem. Soc. 118, 2297-2298. [PDF]

Weatherman, R. V., Mortell, K. H., Chervenak, M., Kiessling, L. L., and Toone, E. J. (1996) Specificity of C-Glycoside complexation by mannose/glucose specific lectins, Biochemistry 35, 3619-3624. [PDF]

Weatherman, R. V. and Kiessling, L. L. (1996) Fluorescence anisotropy assays reveal affinities of C- and O-Glycosides for Concanavalin A, J. Org. Chem. 61, 534-538. [PDF]

Kiessling, L. L. and Pohl, N. L. (1996) Strength in numbers: Non-natural polyvalent carbohydrate derivatives, Chemistry & Biology 3, 71-77. [PDF]


Kiessling, L. L. (1995) Creating molecules: Evolution of randomness. Graven Images 2, 222-228. [PDF]

Manning, D. D., Bertozzi, C. R., Pohl, N. L., Rosen, S. D., and Kiessling, L. L. (1995) Selectin saccharide interactions: Revealing structure function relationships with chemical synthesis, J. Org. Chem. 60, 6254-6255. [PDF]


Mortell, K. H., Gingras, M., and Kiessling, L. L. (1994) Synthesis of cell agglutination inhibitors by aqueous ring-opening metathesis polymerization, J. Am. Chem. Soc. 116, 12053-12054. [PDF]

Sanders, W. and Kiessling, L. L. (1994) Stereoselective Lewis acid-catalyzed glycosylation of cyclic sulfites, Tetrahedron Lett. 35, 7335-7338. [PDF]


Griffin, L. C., Kiessling, L. L, Beal, P. A., Gillespie, P., and Dervan, P. B. (1992) Recognition of all four base pairs of double helical DNA by triple helix formation: Design of non-natural deoxyribonucleosides for pyrimidine-purine base pair binding, J. Am. Chem. Soc. 114, 7976-7982. [PDF]

Kiessling, L. L., Griffin, L. C., and Dervan, P. B. (1992) Flanking sequence effects within the pyrimidine triple helix motif characterized by affinity cleaving, Biochemistry 31, 2829-2834. [PDF]


Hawley, R. C., Kiessling, L. L., Schreiber, S. L. (1989) Model of the interactions of calichemicin g1 with a DNA fragment from pBR322, Proc. Natl. Acad. Sci. USA 86, 1105-1109. [PDF]

Schreiber, S. L. and Kiessling, L. L. (1989) Further investigations of the type II Diels-Alder route to the bicyclic core of esperamicin/calichemicin reveal a regio-chemical misassignment: Meta vs. para selectivity, Tetrahedron Lett. 30, 433-436. [PDF]


Schreiber, S. L. and Kiessling, L. L. (1988) Synthesis of the bicyclic core of the esperamicin/calichemicin class of antitumor agents, J. Am. Chem. Soc. 110, 631-633. [PDF]

Kiessling, L. L. and Schreiber, S L. (1988) Natural product-based leads in cancer chemotherapy, Chemtracts 1, 4-6. [PDF]


Chen, Y. L., Chang, C. W., Hedberg, K., Guarino, K., Welch, W. M., Kiessling, L., Retsema, J., Haskell, S. L., Anderson, M., Manousos, M., and Barrett, J. F. (1987) Structure activity relationships of 6-(heterocyclyl)-methylene penam sulfones: A new class of b-lactamase inhibitors, J. Antibiotics 40, 803-822. [PDF]

Book Chapters:

Kiessling, L. L. and Lamanna, A. C. (2003) Multivalency in Biological Systems, Proceedings of the NATO Symposium Chemical Probes in Biology.

Gestwicki, J. E., Cairo, C. W., Borrok, M. J., and Kiessling, L. L. (2003) Visualization and Characterization of Receptor Clusters by Transmission Electron Microscopy, Methods in Enzymol. 362, 301-312.

Kiessling, L. L. and Mann, D. (2001) The Chemistry and Biology of Multivalent Saccharide Displays, Glycochemistry: Principles, Synthesis and Applications, P. G. Wang and C. R. Bertozzi, Eds.

Kiessling, L. L., Young, T., and Mortell, K. H. (2001) Multivalency in Protein Carbohydrate Recognition, Glycoscience I: Chemistry and Chemical Biology, B. Fraser-Reid, K. Tatsuta, J. Thiem, Eds.

Kiessling, L. L. (1998) The Molecular Recognition of Saccharides and Glycoprotein-Inspired Materials, Recent Trends in Molecular Recognition, Proceedings of the Ernst Schering Research Foundation Workshop 26, 183-212.

Kiessling, L. L. and Strong, L. E. (1998) BioActive Polymers, Topics in Organometallic Chemistry 1: Alkene Metathesis in Organic Synthesis, 199-231.