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Brenda Schilke

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Email: schilke@facstaff.wisc.edu

Brenda graduated with highest honors from University of Illinois (Champaign-Urbana, IL) with a B.S. in microbiology. She entered the graduate program in Bacteriology at the University of Wisconsin-Madison in 1987. She joined Dr. Tim Donohue's lab to study the regulation of cytochrome c2 expression in Rhodobacter sphaeroides. Her first year was funded with a WARF fellowship. Then she was awarded a 3 year NSF pre-doctoral fellowship. She completed her Doctoral thesis in February 1994. She joined Dr. Elizabeth Craig's lab in Biomolecular Chemistry as a post-doctoral student in August 1994. She was awarded a 3 year NSF post-graduate fellowship to study the role of cytosolic chaperones in protein folding of newly synthesized polypeptides in Saccharomyces cerevisiae. She moved to Biochemistry with Dr. Craig as an Associate researcher in May 2002.

Brenda is interested in the process of iron-sulfur cluster assembly in the mitochondria of yeast. Brenda's work is primarily focused on determining the genetics of the iron-sulfur cluster assembly pathway which includes the chaperones SSQ1 and JAC1, and the iron-sulfur cluster scaffold proteins, ISU1 and 2. Additional proteins believed to play a role in iron-sulfur cluster assembly include ISA1 and 2, YFH1, and NFU1.