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Publications since 2000

Oh JH, Schueler KL, Stapleton DS, Alexander LM, Yen CE, Keller MP, Attie AD, van Pijkeren JP. (2020) Secretion of Recombinant Interleukin-22 by Engineered Lactobacillus Reuteri Reduces Fatty Liver Disease in a Mouse Model of Diet-Induced Obesity. mSphere. Jun 24;5(3):e00183-20 PMID 32581074 [PubMed]

Kemis JH, Linke V, Barrett KL, Boehm FJ, Traeger LL, Keller MP, Rabaglia ME, Schueler KL, Stapleton DS, Gatti DM, Churchill GA, Amador-Noguez D, Russell JD, Yandell BS, Broman KW, Coon JJ, Attie AD, Rey FE. (2019) Genetic determinants of gut microbiota composition and bile acid profiles in mice. PLoS Genet. Aug 29;15(8):e1008073 PMID 31465442 [PubMed]

Gupta RK, Attie AD. (2019) Introduction to the Thematic Review Series: Adipose Biology. J Lipid Res. Oct;60(10):1646-1647. PMID 31413067 [PubMed]

Keller MP, Rabaglia ME, Schueler KL, Stapleton DS, Gatti DM, Vincent M, Mitok KA, Wang Z, Ishimura T, Simonett SP, Emfinger CH, Das R, Beck T, Kendziorski C, Broman KW, Yandell BS, Churchill GA, Attie AD.(2019) Gene loci associated with insulin secretion in islets from non-diabetic mice. J Clin Invest. Jul 25;130:4419-4432. PMID 31343992 [PubMed]

Niemi NM, Wilson GM, Overmyer KA, Vögtle FN, Myketin L, Lohman DC, Schueler KL, Attie AD, Meisinger C, Coon JJ, Pagliarini DJ. (2019) Pptc7 is an essential phosphatase for promoting mammalian mitochondrial metabolism and biogenesis. Nat Commun. Jul 19;10(1):3197. PMID 31324765 [PubMed]

Alexander LM, Oh JH, Stapleton DS, Schueler KL, Keller MP, Attie AD, van Pijkeren JP. (2019) Exploiting Prophage-mediated Lysis for Biotherapeutic Release by Lactobacillus reuteri. Appl Environ Microbiol. Jan 25. pii: AEM.02335-18. PMID 30683744 [PubMed]

Oh JH, Alexander LM, Pan M, Schueler KL, Keller MP, Attie AD, Walter J, van Pijkeren JP. (2019) Dietary Fructose and Microbiota-Derived Short-Chain Fatty Acids Promote Bacteriophage Production in the Gut Symbiont Lactobacillus reuteri. Cell Host Microbe. Feb;25(2):273-284.e6. PMID 30658906 [PubMed]

Peng Y, Shapiro SL, Banduseela VC, Dieterich IA, Hewitt KJ, Bresnick EH, Kong G, Zhang J, Schueler KL, Keller MP, Attie AD, Hacker TA, Sullivan R, Kielar-Grevstad E, Arriola Apelo SI, Lamming DW, Anderson RM, Puglielli L. (2018) Increased transport of acetyl-CoA into the endoplasmic reticulum causes a progeria-like phenotype. Aging Cell. Oct;17(5):e12820.
PMID 30051577 [PubMed]

Keller MP, Gatti DM, Schueler KL, Rabaglia ME, Stapleton DS, Simecek P, Vincent M, Allen S, Broman AT, Bacher R, Kendziorski C, Broman KW, Yandell BS, Churchill GA, Attie AD. (2018) Genetic Drivers of Pancreatic Islet Function. Genetics. May;209(1):335-356. PMID 29567659 [PubMed]

Mitok KA, Freiberger EC, Schueler KL, Rabaglia ME, Stapleton DS, Kwiecien NW, Malec PA, Hebert AS, Broman AT, Kennedy RT, Keller MP, Coon JJ, Attie AD. (2018) Islet proteomics reveals genetic variation in dopamine production resulting in altered insulin secretion. J Biol Chem. Apr 20;293(16):5860-5877. PMID 29496998 [PubMed]

Ye R, Gordillo R, Shao M, Onodera T, Chen Z, Chen S, Lin X, SoRelle JA, Li X, Tang M, Keller MP, Kuliawat R, Attie AD, Gupta RK, Holland WL, Beutler B, Herz J, Scherer PE. (2018) Intracellular lipid metabolism impairs β cell compensation during diet-induced obesity. J Clin Invest. Mar 1;128(3):1178-1189. PMID 29457786 [PubMed]

Lin J, Zheng S, Attie AD, Keller MP, Bernlohr DA, Blaner WS, Newberry EP, Davidson NO, Chen A. (2018) Perilipin 5 and liver fatty acid binding protein function to restore quiescence in mouse hepatic stellate cells. J Lipid Res. Mar;59(3):416-428. PMID 29317465 [PubMed]

Yu Q, Canales A, Glover MS, Das R, Shi X, Liu Y, Keller MP, Attie AD, Li L. (2017) Targeted Mass Spectrometry Approach Enabled Discovery of O-Glycosylated Insulin and Related Signaling Peptides in Mouse and Human Pancreatic Islets. Anal Chem. 89(17):9184-9191. PMID 28726377 [PubMed]

Zhang X, Jiang S, Mitok KA, Li L, Attie AD, Martin TFJ. (2017) BAIAP3, a C2 domain-containing Munc13 protein, controls the fate of dense-core vesicles in neuroendocrine cells. J Cell Biol. 216(7):2151-2166. PMID 28626000 [PubMed]

Ye S, Bacher R, Keller MP, Attie AD, Kendziorski C. (2017) Statistical Methods for Latent Class Quantitative Trait Loci Mapping. Genetics. 206(3):1309-1317. PMID 28550015 [PubMed]

Kreznar JH, Keller MP, Traeger LL, Rabaglia ME, Schueler KL, Stapleton DS, Zhao W, Vivas EI, Yandell BS, Broman AT, Hagenbuch B, Attie AD, Rey FE. (2017) Host Genotype and Gut Microbiome Modulate Insulin Secretion and Diet-Induced Metabolic Phenotypes. Cell Rep. 18(7):1739-1750. PMID 28199845 [PubMed]

Attie AD, Churchill GA, Nadeau JH. (2017) How mice are indispensable for understanding obesity and diabetes genetics. Curr Opin Endocrinol Diabetes Obes. 24(2):83-91. PMID 28107248 [PubMed]

Keller MP, Paul PK, Rabaglia ME, Stapleton DS, Schueler KL, Broman AT, Ye SI, Leng N, Brandon CJ, Neto EC, Plaisier CL, Simonett SP, Kebede MA, Sheynkman GM, Klein MA, Baliga NS, Smith LM, Broman KW, Yandell BS, Kendziorski C, Attie AD. (2016) The Transcription Factor Nfatc2 Regulates β-Cell Proliferation and Genes Associated with Type 2 Diabetes in Mouse and Human Islets. PLoS Genet. 12(12)e1006466. PMID 27935966 [PubMed]

Krautkramer KA, Kreznar JH, Romano KA, Vivas EI, Barrett-Wilt GA, Rabaglia ME, Keller MP, Attie AD, Rey FE, Denu JM. (2016) Diet-Microbiota Interactions Mediate Global Epigenetic Programming in Multiple Host Tissues. Mol. Cell. 64(5):982-992. PMID 27889451 [PubMed]

Paul PK, Rabaglia ME, Wang CY, Stapleton DS, Leng N, Kendziorski C, Lewis PW, Keller MP, Attie AD. (2016) Histone chaperone ASF1B promotes human β-cell proliferation via recruitment of histone H3.3. Cell Cycle. 15(23):3191-3202. PMID 27753532 [PubMed]

Chennamsetty I, Coronado M, Contrepois K, Keller MP, Carcamo-Orive I, Sandin J, Fajardo G, Whittle AJ, Fathzadeh M, Snyder M, Reaven G, Attie AD, Bernstein D, Quertermous T, Knowles JW. (2016) Nat1 Deficiency Is Associated with Mitochondrial Dysfunction and Exercise Intolerance in Mice. Cell Rep. 17(2):583-595. PMID 27705799 [PubMed]

Baughman JM, Rose CM, Kolumam G, Webster JD, Wilkerson EM, Merrill AE, Rhoads TW, Noubade R, Katavolos P, Lesch J, Stapleton DS, Rabaglia ME, Schueler KL, Asuncion R, Domeyer M, Zavala-Solorio J, Reich M, DeVoss J, Keller MP, Attie AD, Hebert AS, Westphall MS, Coon JJ, Kirkpatrick DS, Dey A. (2016) NeuCode Proteomics Reveals Bap1 Regulation of Metabolism. Cell Reports. 16:583-595. PMID 27373151 [PubMed]

Knight EM, Ruiz HH, Kim SH, Harte JC, Hsieh W, Glabe C, Klein WL, Attie AD, Buettner C, Ehrlich ME, Gandy S. (2016) Unexpected partial correction of metabolic and behavioral phenotypes of Alzheimer's APP/PSEN1 mice by gene targeting of diabetes/Alzheimer's-related Sorcs1. Acta Neuropathol Commun. 4:16 PMID 26916443 [PubMed]

Tian J, Keller MP, Broman AT, Kendziorski C, Yandell BS, Attie AD, Broman KW. (2016) The Dissection of Expression Quantitative Trait Locus Hotspots. Genetics. 202:1563-1574. PMID 26837753 [PubMed]

Morgan, A.P., Fu, C.P., Kao, C.Y., Welsh, C.E., Didion, J.P., Yadgary, L., Hyacinth, L., Ferris, M.T., Bell, T.A., Miller, D.R., et al. (2015) The Mouse Universal Genotyping Array: From Substrains to Subspecies. G3 (Bethesda). 6:263-279.
PMID 26684931 [PubMed]

Gu, T., Gatti, D.M., Srivastava, A., Snyder, E.M., Raghupathy, N., Simecek, P., Svenson, K.L., Dotu, I., Chuang, J.H., Keller, M.P., et al. (2015) Genetic Architectures of Quantitative Variation in RNA Editing Pathways. Genetics. 202:787-798. PMID 26614740 [PubMed]

Shortreed, M.R., Wenger, C.D., Frey, B.L., Sheynkman, G.M., Scalf, M., Keller, M.P., Attie, A.D., and Smith, L.M. (2015) Global Identification of Protein Post-translational Modifications in a Single-Pass Database Search. J Proteome Res. 14:4714-4720. PMID 26418581 [PubMed]

Attie, A.D. (2015) How do reducing equivalents increase insulin secretion? J Clin Invest. 125:3754-3756. PMID 26389672 [PubMed]

Tian, J., Keller, M.P., Oler, A.T., Rabaglia, M.E., Schueler, K.L., Stapleton, D.S., Broman, A.T., Zhao, W., Kendziorski, C., Yandell, B.S., et al. (2015) Identification of the Bile Acid Transporter Slco1a6 as a Candidate Gene That Broadly Affects Gene Expression in Mouse Pancreatic Islets. Genetics. 201:1253-1262. PMID 26385979 [PubMed]

Savas, J.N., Ribeiro, L.F., Wierda, K.D., Wright, R., DeNardo-Wilke, L.A., Rice, H.C., Chamma, I., Wang, Y.Z., Zemla, R., Lavallee-Adam, M., et al. (2015) The Sorting Receptor SorCS1 Regulates Trafficking of Neurexin and AMPA Receptors. Neuron. 87:764-780. PMID 26291160 [PubMed]

Broman, K.W., Keller, M.P., Broman, A.T., Kendziorski, C., Yandell, B.S., Sen, S., and Attie, A.D. (2015) Identification and Correction of Sample Mix-Ups in Expression Genetic Data: A Case Study. G3 (Bethesda). 5:2177-2186. PMID 26290572 [PubMed]

Shang, J., Li, J., Keller, M.P., Hohmeier, H.E., Wang, Y., Feng, Y., Zhou, H.H., Shen, X., Rabaglia, M., Soni, M., et al. (2015) Induction of miR-132 and miR-212 Expression by Glucagon-Like Peptide 1 (GLP-1) in Rodent and Human Pancreatic beta-Cells. Mol Endocrinol 29:1243-1253. PMID 26218441 [PubMed]

Lai L, Leone TC, Keller MP, Martin OJ, Broman AT, Nigro J, Kapoor K, Koves TR, Stevens R, Ilkayeva OR, Vega RB, Attie AD, Muoio DM, Kelly DP. (2014) Energy Metabolic Re-Programming in the Hypertrophied and Early Stage Failing Heart: A Multi-systems Approach. Circ Heart Fail. PMID 25236884. [PubMed]

Munger SC, Raghupathy N, Choi K, Simons AK, Gatti DM, Hinerfeld DA, Svenson KL, Keller MP, Attie AD, Hibbs MA, Graber JH, Chesler EJ, Churchill GA. (2014) RNA-Seq Alignment to Individualized Genomes Improves Transcript Abundance Estimates in Multiparent Populations. Genetics. 198(1):59-73. PMID 25236449. [PDF] [PubMed]

Johnson LM, Barrick S, Hager MV, McFedries A, Homan EA, Rabaglia ME, Keller MP, Attie AD, Saghatelian A, Bisello A, Gellman SH. (2014) A Potent α/β-Peptide Analogue of GLP-1 with Prolonged Action in Vivo. J Am Chem Soc. 136(37):12848-51. PMID 25191938. [PDF] [PubMed]

Kebede MA, Oler AT, Gregg T, Balloon AJ, Johnson A, Mitok K, Rabaglia M, Schueler K, Stapleton D, Thorstenson C, Wrighton L, Floyd BJ, Richards O, Raines S, Eliceiri K, Seidah NG, Rhodes C, Keller MP, Coon JL, Audhya A, Attie AD. (2014) SORCS1 is necessary for normal insulin secretory granule biogenesis in metabolically stressed β cells. J Clin Invest. 124(10):4240-56. PMID 25157818. [PDF] [PubMed]

Kebede MA, Attie AD. (2014) Insights into obesity and diabetes at the intersection of mouse and human genetics. Trends Endocrinol Metab. 25(10):493-501. PMID 25034129. [PubMed]

Bhatnagar S, Soni MS, Wrighton LS, Hebert AS, Zhou AS, Paul PK, Gregg T, Rabaglia ME, Keller MP, Coon JJ, Attie AD. (2014) Phosphorylation and Degradation of Tomosyn-2 De-represses Insulin Secretion. J Biol Chem. 289(36):25276-86. PMID 25002582. [PDF] [Pubmed]

Soni MS, Rabaglia ME, Bhatnagar S, Shang J, Ilkayeva O, Mynatt R, Zhou YP, Schadt EE, Thornberry NA, Muoio DM, Keller MP, Attie AD. (2014)Downregulation of Carnitine acyl-carnitine translocase by miRNAs 132 and 212 amplifies glucose-stimulated insulin secretion. Diabetes. DB_131677. PMID 24969106. [PubMed]

Martin OJ, Lai L, Soundarapandian MM, Leone TC, Zorzano A, Keller MP, Attie AD, Muoio DM, Kelly DP. (2014) A role for peroxisome proliferator-activated receptor γ coactivator-1 in the control of mitochondrial dynamics during postnatal cardiac growth. Circ Res. 114(4):626-36. PMID 24366168. [PDF] [PubMed]

Ulbrich A, Merrill AE, Hebert AS, Westphall MS, Keller MP, Attie AD, Coon JJ. (2014) Neutron-encoded protein quantification by peptide carbamylation. J Am Soc Mass Spectrom. 1,6-9. PMID 24178922. [PDF] [PubMed]

Kimple, M.E., Keller, M.P., Rabaglia, M.R., Pasker, R.L., Truchan, N.A., Brar, H.K., and Attie, A.D. (2013) Prostaglandin E2 receptor, EP3, is induced in diabetic islets and negatively regulates glucose and hormone-stimulated insulin secretion. Diabetes. 62,1904-1912. PMID 23349487. [PDF] [PubMed]

Neto E.C., Broman A.T., Keller M.P., Attie A.D., Zhang B., Zhu .J, Yandell B.S. (2013) Modeling causality ofr pairs of phenotypes in system genetics. Genetics. 193,1003-1013. PMID  23288936. [PDF] [PubMed]

Lane, R.F., Steele, J.W., Cai, D., Ehrlich, M.E., Attie, A.D., and Gandy, S. (2013) Protein sorting motifs in the cytoplasmic tail of SorCS1 control generation of Alzheimer's amyloid-β peptide. J. Neurosci. 33,7099-7107. PMID 23595767. [PDF]

Haas, M.E. Attie, A.D., and Biddinger, S.B. (2013) The regulation of apoB metabolism by insulin. Trends Endocrinol. Metab.  24, 391-397. PMID 2372961. [PDF]

Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ. (2013) Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation. J. Biol. Chem. 288,26209-26219.
PMID 23864654. [PDF]

O’Halloran, T.V., Kebede, M., Phillips, S.J., and Attie, A.D. (2013) Zinc, insulin and the liver: a ménage a trois. J. Clin. Invest. 123,4136-4139. PMID 24051373. [PDF]

Tu, Z., Keller, M.P., Zhang, C., Rabaglia, M.E., Greenwalt, D.M., Yang, X., Wang, I.M., Dai, H., Bruss, M.D., Lum, P.Y., Zhou, Y.P., Demp, D.M., Dendziorski, C.M., Yandell, B.S., Attie, A.D., Schadt, E.E., Zhu, J. (2012) Integrative analysis of a cross-loci regulation network identifies App as a gene regulating insulin secretion from pancreatic islets. PLoS Genetics. e1003107. PMID 23236292. [PDF]

Grimsrud, P.A., Carson, J.J., Hubler, S.L., Hegert, A.S., Bailey, D.J., Stapleton, D.S., Keller, M.P., Westphall, M.S., Yandell, B.S., Attie, A.D., Coon, J.J., and Pagliarini, D. (2012) A quantitative map of the liver mitochondrial phosphoproteome reveals post-translational control of ketogenesis. Cell Metabolism. 16,672-683. PMID 23140645. [PDF]

Neto EC, Keller MP, Broman A, Attie AD, Jansen RC, Broman KW, and Yandell BS. (2012) Quantile-based permutation thresholds for QTL hotspots. Genetics. 191(4):1355-1365. [PDF]

Wang CY, Stapleton DS, Schueler KL, Rabaglia ME, Oler AT, Keller MP, Kendziorski CM, Broman KW, Yandell BS, Schadt EE, Attie AD. (2012) Tsc2, a positional candidate gene underlying a quantitative trait locus for hepatic steatosis. J Lipid Res. 8,1493-501. PMID 22628617. [PDF]

Casellas J, Gularte RJ, Farber CR, Varona L, Mehrabian M, Schadt EE, Lusis AJ, Attie AD, Yandell BS, and Medrano JF. (2012) Genome scans for transmission ratio distortion regions in mice. Genetics. 191(1):247-59. [PDF]

Bhatnagar S, Oler AT, Rabaglia ME, Stapleton DS, Schueler KL, Truchan NA, Worzella SL, Stoehr JP, Clee SM, Yandell BS, Keller MP, Thurmond DC, and Attie AD. (2011) Positional Cloning of a Type 2 Diabetes Quantitative Trait Locus; Tomosyn‑2, a Negative Regulator of Insulin Secretion. PLoS Genetics. 7,e1002323. [PDF]

Raines SM, Richards OC, Schneider LR, Schueler KL, Rabaglia ME, Oler AT, Stapleton DS, Genové G, Dawson C, and Attie AD. (2011) Loss of PDGF-B activity increases hepatic vascular delivery of insulin and enhances insulin sensitivity. Am. J. Physiol. Endocrinol. Metab. 301,517-526. [PDF]

Wang P, Dawson JA, Keller MP, Yandell BS, Thornberry NA, Zhang BB, Wang IM, Schadt EE, Attie AD, and Kendziorski CM. (2011) A Model Selection Approach for Expression Quantitative Trait Loci (eQTL) Mapping. Genetics. 187, 611-621. [PDF]

Keller MP and Attie AD. (2010) Physiological insights gained from gene expression analysis in obesity and diabetes.
Ann. Rev. Nutr. 30,341-364. [PDF]

Zhong H, Beaulaurier J, Lum PY, Molony C, Yang X, MacNeil DJ, Weingarth DT, Zhang B, Greenawalt D, Dobrin R, Hao K, Woo S, Fabre-Suver C, Qian S, Tota MR, Keller MP, Kendziorski, CM, Yandell BS, Caxtro V, Attie AD, Kaplan LM, Schadt EE. (2010) Liver and adipose expression associated SNPs are enriched for association to type 2 diabetes. PLoS Genetics. 6(5):e1000932. [PDF]

Lavine, JA, Raess PW, Stapleton DS, Rabaglia ME, Suhonen JI, Schueler KL, Koltes JE, Dawson JA, Yandell BS, Samuelson LC, Beinfeld MC, Davis DB, Hellerstein MK, Keller M.P, And Attie AD. (2010) Cholecystokinin is Up-regulated in obese islets and expands beta-cell mass by increasing beta-cell survival. Mol. Endocrinol. 151, 3577-3588. [PDF]

Hudkins K, Pichaiwong W, Wietecha T, Kowalewska J, Banas M, Spencer M, Mühlfeld A, Koelling M, Pippin J, Shankland S, Askari B, Rabaglia ME, Keller MP, Attie AD, Alpers CE. (2010) BTBR Ob/Ob mutant mice model progressive diabetic nephropathy. J. Am. Soc. Nephrol. 21, 1553-1542. [PDF]

Davis DB, Lavine JA, Suhonen JI, Krautkramer KA, Rabaglia ME, Sperger JM, Fernandez LA, Yandell B.S., Keller MP, Wang IM, Schadt EE, and Attie AD (2010) FoxM1 is up-regulated by obesity and stimulates beta-cell proliferation. Mol. Endocrinol. 24, 1822-1834. [PDF]

Babak T, Garrett-Engele P, Armour CD, Raymond CK, Keller MP, Chen R, Rohl CM, Johnson JM, Attie AD, Fraser HB, and Schadt EE. (2010) Genetic validation of whole-transcriptome sequencing for mapping cis-regulatory variation. BMC Genomics. 11, 473. [PDF]

Attie AD and Keller MP. (2010) Gene co-expression modules and type 2 diabetes. Results Probl Cell Differ. 52, 47-56. PMID: 20865371.

Lane RF, Raines SM, Steele JW, Ehrlich ME, Lah JA, Small SA, Tanzi RE, Attie AD, Gandy S. Diabetes-associated SorCS1 regulates Alzheimer's amyloid-beta metabolism: evidence for involvement of SorL1 and the retromer complex.
J. Neurosci. 30, 13110-13115. PMID: 20881129 [PDF]

Lavine JA and Attie AD. (2010) Gastrointestinal hormones and the regulation of beta-cell mass. Ann NY Acad Sci. 12,41-58. [PDF]

Neto EC, Keller MP, Attie AD, and Yandell BS. (2010) Causal graphical models in systems genetics: A unified framework for joint inference of causal network and genetic architecture for correlated phenotypes. Ann Appl Stat. 4(1):320-339. [PDF]

Newgard CB, Attie AD. (2010) Getting biological about the genetics of diabetes. Nat Med. 16(4):388-91. [PDF]

Richards OC, Raines SM, Attie AD. (2010) The role of blood vessels, endothelial cells, and vascular pericytes in insulin secretion and peripheral insulin action. Endocr Rev. 31(3):343-63. [PDF] supplemental: [PDF]

Zhao E, Keller MP, Rabaglia ME, Oler AT, Stapleton DS, Schueler KL, Neto EC, Moon JY, Wang P, Wang IM, Lum PY, Ivanovska I, Cleary M, Greenawalt D, Tsang J, Choi YJ, Kleinhanz R, Shang J, Zhou YP, Howard AD, Zhang BB, Kendziorski C, Thornberry NA, Yandell BS, Schadt EE, Attie AD. (2009) Obesity and genetics regulate microRNAs in islets, liver, and adipose of diabetic mice. Mamm Genome. 20(8):476-85. [PDF]

Rieck S, White P, Schug J, Fox AJ, Smirnova O, Gao N, Gupta RK, Wang ZV, Scherer PE, Keller MP, Attie AD, Kaestner KH. (2009) The transcriptional response of the islet to pregnancy in mice. Mol Endocrinol. 23(10):1702-12. [PDF] supplimental: [PDF]

Halberg N, Khan T, Trujillo ME, Wernstedt-Asterholm I, Attie AD, Sherwani S, Wang ZV, Landskroner-Eiger S, Dineen S, Magalang UJ, Brekken RA, Scherer PE. (2009) Hypoxia-inducible factor 1alpha induces fibrosis and insulin resistance in white adipose tissue. Mol Cell Biol. 29(16):4467-83. [PDF]

Attie AD, Scherer PE. (2009) Adipocyte metabolism and obesity. J Lipid Res. 50 Suppl:S395-9. Review. [PDF]

Lusis AJ, Attie AD, Reue K. (2008) Metabolic syndrome: from epidemiology to systems biology. Nat Rev Genet. 9(11):819-30. Review. [PDF]

Attie AD, Witztum JL, Edwards PA, Lusis AJ. (2008) In Memoriam: Roger A. Davis (1945-2008). J Lipid Res. 49(11):2279-80. [PDF]

Chen J, Hui ST, Couto FM, Mungrue IN, Davis DB, Attie AD, Lusis AJ, Davis RA, Shalev A. (2008) Thioredoxin-interacting protein deficiency induces Akt/Bcl-xL signaling and pancreatic beta-cell mass and protects against diabetes. FASEB J. 22(10):3581-94. [PDF] supplimental: [PDF]

Davis RA, Attie AD. (2008) Deletion of the ileal basolateral bile acid transporter identifies the cellular sentinels that regulate the bile acid pool. Proc Natl Acad Sci USA. 1;105(13):4965-6. [PDF]

Chaibub Neto E, Ferrara CT, Attie AD, Yandell BS. (2008) Inferring causal phenotype networks from segregating populations. Genetics. 179(2):1089-1100. [PDF]

Keller MP, Choi Y, Wang P, Belt Davis D, Rabaglia ME, Oler AT, Stapleton DS, Argmann C, Schueler KL, Edwards S, Steinberg HA, Chaibub Neto E, Kleinhanz R, Turner S, Hellerstein MK, Schadt EE, Yandell BS, Kendziorski C, Attie AD. (2008) A gene expression network model of type 2 diabetes links cell cycle regulation in islets with diabetes susceptibility. Genome Res. 18(5):706-716. [PDF]

Blasiole DA, Oler AT, Attie AD. (2008) Regulation of ApoB secretion by the low density lipoprotein receptor requires exit from the endoplasmic reticulum and interaction with ApoE or ApoB. J Biol Chem. 283(17):11374-11381. [PDF]

Ferrara CT, Wang P, Neto EC, Stevens RD, Bain JR, Wenner BR, Ilkayeva OR, Keller MP, Blasiole DA, Kendziorski C, Yandell BS, Newgard CB, Attie AD. (2008) Genetic networks of liver metabolism revealed by integration of metabolic and transcriptional profiling. PLoS Genet. 4(3):1000034. [PDF]

Flowers MT, Keller MP, Choi Y, Lan H, Kendziorski C, Ntambi JM, Attie AD. (2008) Liver gene expression analysis reveals endoplasmic reticulum stress and metabolic dysfunction in SCD1-deficient mice fed a very low-fat diet. Physiol Genomics. 33(3):361-372. [PDF]

Oler AT, Attie AD. (2008) A rapid, microplate SNP genotype assay for the leptinob allele. J Lipid Res. 49(5):1126-1129. [PDF]

Blasiole D.A., Davis R.A., Attie A.D. (2007) The physiological and molecular regulation of lipoprotein assembly and secretion. Mol Biosyst. 3(9):608-19. [PDF]

Nassoury, N., Blasiole, D., Oler, A.T., Hamelin, J., Prat, A., Attie, A.D., and Seidah, N.G. (2007) The cellular trafficking of the secretory proprotein convertase PCSK9 and its dependence on the LDLR. Traffic.  8, 718-732. [PDF]

Goodarzi, M.O., Lehman, D.M., Taylor, K.D., Guo, X., Cui, J., Quiñones, J.J., Clee, S.M., Hsueh, W.A., Yang, H., Attie, A.D., Stern, M.P., Rotter, J.I. (2007) SORCS1: A novel human type 2 diabetes susceptibility gene suggested by the mouse. Diabetes. 56, 1922-1929. [PDF]

Clee, S.M. and Attie, A.D. The genetic landscape of type 2 diabetes in mice. Endocrine Reviews. 28(1):48-83. [PDF]

Attie, A.D., Sober, E., Numbers, R.L., Amasino, R.M., Cox, B., Berceau, T., Powell, T., and Cox, M.M. (2006) Defending science education against intelligent design: a call to action. J. Clin. Invest. 116, 1134-1138. [PDF]

Attie, A.D. (2006) A Liver-High-Density Lipoprotein-Ovarian Axis of Fertility. Endocrinology. 147(4):1575-1576. [PDF]

Clee, S.M., Yandell, B.S., Schueler, K.M., Rabaglia, M.E., Richards, O.C., Raines, S.M., Kabara, E.A., Klass, D.M., Stapleton, D.S., Gray-Keller, M.P., Boronenkov, I., Raess, P.W., Flowers, M.T., and Attie, A.D. (2006) Positional cloning of a type 2 diabetes quanitative trait locus. Nature Genetics. 38, 688-693. [PDF]

Lan, H. Chen, M., Byers, J.E., Yandell, B.S., Stapelton, D.S., Mata, C.M., Mui, E.T., Flowers, M.T., Scheuler, K.L., Manly, K.F., Williams, R.W., Kendziorski, C.M., Attie, A.D. (2006) Combined expression trait correlations and expression quantative trait locus mapping. PLoS Genetics. 2:52-61. [PDF]

Kendziorski, C. M. ,Chen, M., Yuan, M., Lan, H. and Attie, A. D. (2005) Statistical Methods for Expression Quantitative Trait Loci (eQTL) Mapping. Biometrics. DOI: 10.1111/j.1541-0420. [PDF]

Rabagia, M.E., Gray-Keller, M.P., Attie, A.D. (2005) α-Ketoisocaproate-induced Hypersecretion of Insulin by Islets from Diabetes-susceptible Mice: A Role for α-ketoglutarate as a direct insulin secretagogue. Am. J. Physiol. 289, E218-E224. [PDF]

Minn, A.H., Lan, H., Rabaglia, M.E., Harlan, D.M., Peculis, B.A., Attie, A.D., and Shalev, A. (2005) Increased insulin translation from an insulin splice-variant overexpressed in diabetes and insulin resistance. Mol. Endocrinol. 19, 794-803. [PDF]

Clee, S.M., Nadler, S.T., Attie, A.D. (2005) Genetic and genomic studies in the BTBR ob/ob Model of type 2 diabetes.
Am. J. Ther. 12, 491-498. [PDF]

Sheth, S.S., Castellani, L.W., Chari, S., Wagg, C., Thipphavong, C.K., Bodnar, J.S., Tontonoz, P., Attie, A.D., Lopaschuk, G.D., and Lusis, A.J. (2005) Thioredoxin interacting protein (Txnip) deficiency disrupts the fasting-feeding metabolic transition.  J. Lipid Res. 46, 123-134. [PDF]

Benjannet S, Rhainds D, Essalmani R, Mayne J, Wickham L, Jin W, Asselin MC, Hamelin J, Varret M, Allard D, Trillard M, Abifadel M, Tebon A, Attie AD, Rader DJ, Boileau C, Brissette L, Chretien M, Prat A, Seidah NG. (2004) NARC-1/PCSK9 and its natural mutants: zymogen cleavage and effects on the low density lipoprotein (LDL) receptor and LDL cholesterol.
J Biol Chem. 279, 48865-75. [PDF]

Jin, C., Lan, H., Attie, A.D., Bulutuglo, D., Churchill, G.A., and Yandell, B.S. (2004) Selective phenotyping for increased efficiency in mapping studies. Genetics. 168, 2285-93. [PDF]

Hui, T.Y., Sheth, S., Diffley, J.M., Potter, D.W., Lusis, A.J., Attie, A.D., and Davis, R.A. (2004) Mice lacking thiroedoxin interactin protein provide evidence linking cellular redox state to appropriate response to nutritional signals. J. Biol. Chem. 279, 24387-24851. [PDF]

Attie, A.D. (2004) Insig: a significant integrator of hormonal and nutritional signals. J. Clin. Invest. 113, 1112-1114. [PDF]

Attie, A.D. (2004) The mystery of PCSK9. Arteroscl. Thromb. Vasc. Biol. 24,1337-1339. [PDF]

Lan, H., Rabaglia, M.E., Schueler, K.L., Mata, C., Yandell, B.S., and Attie, A.D. (2004) Distinguishing co-variation from causality in diabetes: a lesson from the protein disulfide isomerase mRNA abundance trait. Diabetes. 53, 240-244. [PDF]

Stoehr, J.P., Byers, J.E., Clee, S.M., Lan, H., Boronenkov, I., Schueler, K.M., Yandell, B.S., and Attie, A.D. (2004) Identification of major quantitative trait loci controlling body weight variation in ob/ob mice. Diabetes. 53, 245-249. [PDF]

Lan, H., Rabaglia, M.E., Stoehr, J.P., Nadler, S.T., Schueler, K.L., Zou, F., Yandell, B.S., and Attie, A.D. (2003) Gene expression profiles of non-diabetic and diabetic obese mice suggest a role of hepatic lipogenic capacity in diabetes susceptibility. Diabetes. 52, 688-700. [PDF]

Lan, H., Stoehr, J.P., Nadler, S.T, Schueler, K.M., Yandell, B.S., and Attie, A.D. (2003) Dimension reduction for mapping mRNA abundance as quantitative traits. Genetics. 164, 1607-1614. [PDF]

Lin, Y., Nadler, S.T., Lan, H., Attie, A.D., and Yandell, B.S. (2003) Adaptive gene picking with microarray data: detecting important low abundance signals. In: The Analysis of Gene Expression Data: Methods and Software, ed by G Parmigiani, ES Garrett, RA Irizarry, SL Zeger. Springer-Verlag. [PDF]

C.M. Kendziorski, Y. Zhang, H. Lan, A.D. Attie, (2003) The efficiency of pooling mRNA in microarray experiments. Biostatistics. 465-477. [PDF]

Lin, Y., Nadler, S.T., Lan, H., Attie, A.D., and Yandell, B.S. (2002) Adaptive gene picking with microarray data: detecting important low abundance signals. In: The Analysis of Gene Expression Data: Methods and Software, ed by G Lan, H., Rabaglia, M.E., Stoehr, J.P. 

Ntambi, J.M., Miyazaki, M., Stoehr, J.P., Lan, H., Kendziorski, C.M., Yandell, B.S., Cohen, P., Friedman, J.M., and Attie, A.D. (2002) Loss of Stearoyl CoA Desaturase-1 Function Protects mice against adiposity. Proc. Natl. Acad. Sci. USA 99, 11482-11486. [PDF]

Attie, A.D., Hamon, Y., Brooks-Wilson, A.R., Gray-Keller, M.P., MacDonald, M.L.E., Rigot, V., Tebon, A., Zhang, L-H., Mulligan, J., Singaraja, R.R., Bitgood, J.J., Cook, M.E., Kastelein, J.J.P., Chimini, G., and Hayden, M.R. (2002) Identification and functional analysis of a naturally occurring E89K mutation in the ABCA1 gene of the WHAM chicken. J. Lipid Res. 43, 1610-1617. [PDF]

Attie, A.D., Krauss, R.M., Gray-Keller, M.P., Brownlie, A., Miyazaki, M., Kastelein, J.J., Lusis, A.J., Stalenhoef, A.F.H., Stoehr, J.P., Hayden, M.R., and Ntambi, J.M. (2002) Relationship between stearoyl-CoA desaturase activity and plasma triglycerides in human and mouse hypertriglyceridemia. J. Lipid Res. 43, 1899-1907. [PDF]

Gillian-Daniel, Donald L., Bates, Paul W., Tebon, Angie, and Attie, Alan D. (2002) Endoplasmic reticulum localization of the low density lipoprotein receptor mediates presecretory degradation of apolipoprotein B. PNAS 99(7):4337-4342. [PDF]

Attie, A.D., Kastelein, J.P., and Hayden, M.R. (2001) Pivotal role of ABCA1 in reverse cholesterol transport influencing HDL levels and susceptibility to atherosclerosis. J. Lipid Res. 42,1717-1726. [PDF]

Nadler, S.T., Stoehr, J.P., Rabaglia, M.A., Schueler, K.L., Birnbaum, M.J., and Attie, A.D. (2001) Normal Akt/PKB with reduced PI3K activation in insulin-resistant mice. Am. J. Physiol. 249, E1249-E1254. [PDF]

Nadler, S.T. and Attie, A.D. (2001) Please pass the chips. Genomic Insights into obesity and diabetes. 
J. Nutrition. 131, 2078-2081. [PDF]

Stoehr, J.P., Nadler, S.T., Schueler, K.L., Rabaglia, M.E., Yandell, B.S., Metz, S.A., and Attie, A.D. (2000) Genetic obesity unmasks non-linear interactions between murine Type 2 Diabetes susceptibility loci. Diabetes. 49, 1946-1954. [PDF]

Nadler, S.T., Stoehr, J.P., Schueler, K.M., Tanimoto, G., Yandell, B.S., and Attie, A.D. (2000) The expression of adipogenic genes is decreased in obesity and diabetes mellitus.  Proc. Natl. Acad. Sci. USA. 97, 11371-11376. [PDF]

Twisk, J., Gillian-Daniel, D.L., Tebon, A., Barrett, P.H.R., and Attie, A.D. (2000) The role of the LDL receptor in apolipoprotein B secretion.  J. Clin. Invest. 105, 521-532. [PDF]