Judith Kimble

Photo of Judith Kimble
Vilas Professor
Howard Hughes Medical Institute Investigator
(also in Laboratory of Molecular Biology, Department of Medical Genetics, and Department of Cell and Regenerative Biology)
A.B., University of California, Berkeley
Ph.D., University of Colorado, Boulder
Phone: (608) 262-6188
Email: jekimble@wisc.edu

Publications

189. Greider C, Hopkins N, Steitz J, Amon A, Asai D, Barres B, Bass B, Bassler B, Birgeneau R, Bjorkman P, Botchan M, Brugge J, Cech T, Colwell R, Craig N, deLange T, Eisen M, Gottesman S, Green R, Handelsman J, Kimble J, King MC, Lehmann R, Marder E, Mullins D, O'Shea E, Schmid S, Seydoux G, Spradling A, Storz G, Szostak J, Telesnitsky A, Tilghman S, Tjian R, Vale R, Wolberger C, Zakian V. ( 2017) Not just Salk. Science 357(6356), 1105-1106. [PDF] [PubMed]

188. Crittenden SL, Seidel HS, Kimble J. (2017) Analysis of the C. elegans Germline Stem Cell Pool. Methods Mol Biol. 1463, 1-33. [PubMed]

187. Lee C, Sorensen EB, Lynch TR, Kimble J. (2016) C. elegans GLP-1/Notch activates transcription in a probability gradient across the germline stem cell pool. eLife 5, pii: e18370. [PDF] [PubMed]

186. Prasad A, Porter DF, Kroll-Conner PL, Mohanty I, Ryan AR, Crittenden SL, Wickens M, Kimble J. (2016) The PUF binding landscape in metazoan germ cells. RNA 22(7), 1026-1043.[PDF] [PubMed]

185. Aoki ST, Kershner AM, Bingman CA, Wickens M, Kimble J. (2016) PGL germ granule assembly protein is a base-specific, single-stranded RNase. PNAS USA 113(5), 1279-1284. [PDF] [PubMed]

184. Noble DC, Aoki ST, Ortiz MA, Kim KW, Verheyden JM, Kimble J. (2016) Genomic Analyses of Sperm Fate Regulator Targets Reveal a Common Set of Oogenic mRNAs in Caenorhabditis elegans. Genetics 202(1), 221-234. [PDF] [PubMed]

183. Seidel HS, Kimble J. (2015) Cell-cycle quiescence maintains Caenorhabditis elegans germline stem cells independent of GLP-1/Notch. eLife 4, pii: e10832. [PDF] [PubMed]

182. Rhoads TW, Prasad A, Kwiecien NW, Merrill AE, Zawack K, Westphall MS, Schroeder FC, Kimble J, Coon JJ. (2015) NeuCode Labeling in Nematodes: Proteomic and Phosphoproteomic Impact of Ascaroside Treatment in Caenorhabditis elegans. Molecular & cellular proteomics : MCP. 14(11), 2922-2935. [PDF] [PubMed]

181. Kimble J, Bement WM, Chang Q, Cox BL, Drinkwater NR, Gourse RL, Hoskins AA, Huttenlocher A, Kreeger PK, Lambert PF, Mailick MR, Miyamoto S, Moss RL, O'Connor-Giles KM, Roopra A, Saha K, Seidel HS (2015) Strategies from UW-Madison for rescuing biomedical research in the US. eLife 4, e09305. [PDF] [PubMed]

180. Friend K, Brooks HA, Propson NE, Thomson JA, Kimble J. (2015) Embryonic Stem Cell Growth Factors Regulate eIF2α Phosphorylation. PloS one 10(9), e0139076. [PDF] [PubMed]

179. Sorokin, E.P., Gasch, A.P. and J. Kimble (2014) Competence for chemical reprogramming of sexual fate correlates with an intersexual molecular signature in Caenorhabditis elegans. Genetics 198(2),561-575. [PDF] [PubMed]

178. Ortiz, M.A., Noble, D., Sorokin E.P. and J. Kimble (2014) A new dataset of spermatogenic vs. oogenic transcriptomes in the nematode Caenorhabditis elegans. G3.4(9), 1765-1772. [PDF] [PubMed]

177. Kershner, A.M., Shin, H., Hansen, T.J. and J. Kimble (2014) Discovery of two GLP-1/Notch target genes that account for the role of GLP-1/Notch signaling in stem cell maintenance. PNAS 111(10), 3739-3744. [PDF] [PubMed]

176. Byrd, D.T., Knobel, K., Affeldt, K., Crittenden, S.L. and J. Kimble (2014) A DTC niche plexus surrounds the germline stem cell pool in Caenorhabditis elegans. PLoS One 9(2), e88372. [PDF] [PubMed]

175. Kimble, J. and H. Seidel (2013) C. elegans germline stem cells and their niche (November 15, 2013), StemBook, ed. The Stem Cell Research Community, StemBook, doi/10.3824/stembook.1.95.1. [PDF] [PubMed] [StemBbook]

174. Kershner, A., Crittenden, S.L., Friend, K., Sorensen, E.B., Porter, D.F., and J. Kimble (2013) Germline stem cells and their regulation in the nematode Caenorhabditis elegans. In Transcriptional and Translational Regulation of Stem Cells (eds. G. Hime & H. Abud). (Springer) Advances in Experimental Medicine and Biology 786, pp. 29-46. (Dordrecht: Springer Science+Business Media). [PubMed]

173. Morgan, C.T., Noble, D., and J. Kimble (2013) The mitosis–meiosis and sperm–oocyte fate decisions are separable regulatory events. PNAS 110(9), 3411-3416. [PDF] [PubMed]

172. Snow, J.J., Lee, M.-H., Verheyden, J., Kroll-Conner, P.L., and J. Kimble (2013) C. elegans FOG-3/Tob can either promote or inhibit germline proliferation, depending on gene dosage and genetic context. Oncogene 32, 2614-2621. [PDF] [PubMed]

171. LeGendre, J.B., Campbell, Z.T., Kroll-Conner, P., Anderson, P., Kimble, J., and M. Wickens (2013) RNA targets and specificity of Staufen, a double-stranded RNA-binding protein in Caenorhabditis elegans. J Biol Chem 288(4), 2532-2545.[PDF] [PubMed]

170. Buckley, B., Burkhart, K., Gu, S.G., Spracklin, G., Kershner, A., Fritz, H., Kimble, J., Fire, A. and S. Kennedy (2012) A nuclear Argonaute promotes multi-generational epigenetic inheritance and germline immortality. Nature 489, 447-451. [PDF] [PubMed]

169. Cha, D.S., Datla, U.S., Hollis, S.E., Kimble, J., and M.-H. Lee (2012) The Ras-ERK MAPK regulatory network controls dedifferentiation in Caenorhabditis elegans germline. Biochimica et Biophysica Acta – Molecular Cell Research 1823(10), 1847-1855. [PDF] [PubMed]

168. Martynovsky, M., Wong, M.-C., Byrd, D.T., Kimble, J. and J.E. Schwarzbauer (2012) mig-38, a novel gene that regulates distal tip cell turning during gonadogenesis in C. elegans hermaphrodites. Developmental Biology 368(2), 404-414. [PDF] [PubMed]

167. Campbell, Z.T., Menichelli, E., Friend, K., Wu, J., Kimble, J., Williamson, J.R., and M. Wickens (2012) Identification of a conserved interface between PUF and CPEB proteins. J Biol Chem 287(22), 18854-18862. [PDF] [PubMed]

166. Lander, A.D., Kimble, J., Clevers, H., Fuchs, E., Montarras, D., Buckingham, M., Calof, A.L., Trumpp, A. and T. Oskarsson (2012) What does the concept of the stem cell niche really mean today? BMC Biology 10, 19. [PDF] [BMC]

165. Qiu, C., Kershner, A., Wang, Y., Holley, C.P., Wilinski, D., Keles, S., Kimble, J., Wickens, M. and T.M.T. Hall (2012) Divergence of Pumilio/fem-3 mRNA binding factor (PUF) protein specificity through variations in an RNA-binding pocket. J. Biol. Chem. 287(9), 6949-6957. [PDF] [PubMed]

164. Friend, K., Campbell, Z.T., Cooke, A., Kroll-Conner, P., Wickens, M.P. and J. Kimble (2012) A conserved PUF/Ago/eEF1A complex attenuates translation elongation. Nature Structural and Molecular Biology 19(2), 176-183. [PDF] [PubMed]

163. Seidel, H.S. and J. Kimble (2011) The oogenic germline starvation response in C. elegans. PLoS One 6(12), e28074. [PDF] [PubMed]

162. Kimble, J. (2011) Molecular regulation of the mitosis/meiosis decision in multicellular organisms. Cold Spring Harbor Perspect Biology. doi: 10.1101/cshperspect.a002683. [PDF] [PubMed]

161. Lee, M.-H., Kim, K.W., Morgan, C.T., Morgan, D.E. and J. Kimble (2011) Phosphorylation state of a Tob/BTG protein, FOG-3, regulates initiation and maintenance of the Caenorhabditis elegans sperm fate program. PNAS 108, 9125-9130. [PDF] [PubMed]

160. Hinde, E., Cardarelli, F, Digman, M.A., Kershner, A., Kimble, J. and E. Gratton (2011) The impact of mitotic versus interphase chromatin architecture on the molecular flow of EGFP by pair correlation analysis. Biophysical Journal 100, 1829-1836. [PDF] [PubMed]

159. Jeong, J., Verheyden, J.M. and J. Kimble (2011) Cyclin E and Cdk2 control GLD-1, the mitosis/meiosis decision, and germline stem cells in Caenorhabditis elegans. PLoS Genetics 7, e1001348. [PDF] [PubMed]

158. Kim, K.W, Wilson, T.L. and J. Kimble (2010)  The GLD-2/RNP-8 cytoplasmic poly(A) polymerase is a broad-spectrum regulator of the oogenesis program. PNAS 107, 17445-17450. [PDF] [PubMed]

157. Morgan, D., Crittenden, S.L. and J. Kimble (2010) The C. elegans adult male germline: stem cells and sexual dimorphism. Developmental Biology 346, 204-214. [PDF] [PubMed]

156. Kershner, A. and J. Kimble (2010) Genome-wide analysis of mRNA targets for Caenorhabditis elegans FBF, a conserved stem cell regulator. PNAS 107, 3936-3941. [PDF] [PubMed]

155. Cinquin, O., Crittenden, S.L., Morgan, D.E. and J. Kimble (2010) Progression from a stem cell-like state to early differentiation in the C. elegans germ line. PNAS 107, 2048-2053. [PDF] [PubMed]

154. Morgan, C.T., Lee, M.-H., and J. Kimble (2010) Chemical reprogramming of Caenorhabditis elegans germ cell fate. Nature Chemical Biology 6, 102-104. [PDF] [PubMed]

153. Byrd, D.T. and J. Kimble (2009) Scratching the niche that controls Caenorhabditis elegans germline stem cells. Seminars in Cell & Developmental Biology 20, 1107-1113. [PDF] [PubMed]

152. Phillips, B and J. Kimble (2009) A new look at TCF and β-catenin through the lens of a divergent C. elegans Wnt pathway. Developmental Cell 17, 27-34. [PDF] [PubMed]

151. Chesney, M.A., Lam, N., Morgan, D.E., Phillips, B.T. and J. Kimble (2009) C. elegans HLH-2/E/Daughterless controls key regulatory cells during gonadogenesis. Developmental Biology 331, 14-25. [PDF] [PubMed]

150. Kim, K.W., Nykamp, K., Suh, N., Bachorik, J.L., Wang, L. and J. Kimble (2009) Antagonism between GLD-2 binding partners controls gamete sex. Developmental Cell 16, 723-733. [PDF] [PubMed]

149. Crittenden, S. and J. Kimble (2009) Preparation and immunolabeling of Caenorhabditis elegans. CSH Protocols 2009(5), pdb prot5216. [PDF] [PubMed]

148. Suh, N., Crittenden, S.L., Goldstrohm, A., Hook, B., Thompson, B., Wickens, M. and J. Kimble (2009) FBF and its dual control of gld-1 expression in the Caenorhabditis elegans germline. Genetics 181, 1249-1260. [PDF] [PubMed]

147. King, R.S., Maiden, S.L., Hawkins, N.C., Kidd, A.R., Kimble, J., Hardin J., and T.D. Walston (2009) The N- or C-terminal domains of DSH-2 can activate the C. elegans Wnt/β-catenin asymmetry pathway. Developmental Biology 328(2), 234-244. [PDF] [PubMed]

146. Stumpf, C.R., J. Kimble and M. Wickens (2008) A Caenorhabditis elegans PUF protein family with distinct RNA binding specificity. RNA 14, 1550-1557. [PDF] [PubMed]

145. Nykamp, K., M.-H. Lee and J. Kimble (2008) C. elegans La-related protein, LARP-1, localizes to germline P bodies and attenuates Ras-MAPK signaling during oogenesis. RNA 14, 1378-1389. [PDF] [PubMed]

144. Liu, J., B.T. Phillips, M.F. Amaya, J. Kimble and W. Xu (2008) The C. elegans SYS-1 protein is a bona-fide β-catenin. Developmental Cell 14, 751-761. [PDF] [PubMed]

143. Crittenden, S.L. and J. Kimble (2008) Analysis of the C. elegans germline stem cell region. In Germline Stem Cells, edited by Steven X. Hou and Shree Ram Singh. Methods in Molecular Biology 450, 27-44. [PubMed]

142. Lee, M-H., B. Hook, G. Pan, A.M. Kershner, C. Merritt, G. Seydoux, J.A. Thomson, M. Wickens and J. Kimble (2007) Conserved regulation of MAP kinase expression by PUF RNA-binding proteins. PLoS Genetics 3(12), e233. [PDF] [PubMed]

141. Kimble, J. and S.L. Crittenden (2007) Controls of germline stem cells, entry into meiosis, and the sperm/oocyte decision in Caenorhabditis elegans. Ann. Rev. Cell Dev. Biol. 23, 405-433. [PDF] [PubMed]

140. Kimble, J. and D.C. Page (2007) The mysteries of sexual identity: the germ cell’s perspective. Science 316, 400-401. [PDF] [PubMed]

139. Lamont, L.B. and J. Kimble (2007) Developmental expression of FOG-1/CPEB protein and its control in the Caenorhabditis elegans hermaphrodite germ line. Developmental Dynamics 236(3), 871-879. [PDF] [PubMed]

138. Phillips, B.T., A.R. Kidd III, R. King, J. Hardin and Kimble (2007) Reciprocal asymmetry of SYS-1/β-catenin and POP-1/TCF controls asymmetric divisions in Caenorhabditis elegans. PNAS 104(9), 3231-3236. [PDF] [PubMed]

137. Thompson, B., M. Wickens and J. Kimble (2007) Translational control in development. In Translational Control in Biology and Medicine (M.B. Mathews, N. Sonenberg, J.W.B. Hershey, eds). Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press, pp. 507-544.

136. Hesselson, D. and J. Kimble (2006) Growth control by EGF-repeats of the C. elegans Fibulin-1C isoform. J. Cell Biol. 175(2), 217-223. [PDF] [PubMed]

135. Suh, N., C.R. Eckmann, M. Wickens and J. Kimble (2006) The GLD-2 poly(A) polymerase activates gld-1 mRNA in the C. elegans germ line. PNAS 103(41), 15208-15112. [PDF] [PubMed]

134. Morrison, S.J. and J. Kimble (2006) Asymmetric and symmetric stem-cell divisions in development and cancer. Nature 441, 1068-1074. [PDF] [PubMed]

133. Crittenden, S.L., K.A. Leonhard, D.T. Byrd and J. Kimble (2006) Cellular analyses of the mitotic region in the Caenorhabditis elegans adult germ line. Molecular Biology of the Cell 17(7), 3051-3061. [PDF] [PubMed]

132. Lam, N., M.A. Chesney and J. Kimble (2006) Wnt signaling and CEH-22/tinman/Nkx2.5 specify a stem cell niche in C. elegans. Current Biology 16, 287-295. [PDF] [PubMed]

131. Chesney, M.A., A.R. Kidd III and J. Kimble (2006) gon-14 functions with class B and class C synthetic multivulva genes to control larval growth in Caenorhabditis elegans. Genetics 172, 915-928. [PDF] [PubMed]

130. Thompson, B.E., L.B. Lamont and J. Kimble (2006) Germ-line induction of the Caenorhabditis elegans vulva. PNAS 103(3), 620-625. [PDF] [PubMed]

129. Lee, M.H., B. Hook, L.B. Lamont, M. Wickens and J. Kimble (2006) LIP-1 phosphatase controls the extent of germline proliferation in C. elegans. The EMBO Journal 25(1), 88-96. [PDF] [PubMed]

128. Crittenden, S. and J. Kimble (2006) Immunofluorescence methods for Caenorhabditis elegans. In Basic Methods in Microscopy: Protocols and Concepts from Cells: A Laboratory Manual (D.L. Spector and R.D. Goldman, eds). pp. 193-200. [PDF]

127. Tilmann, C. and J. Kimble (2005) Cyclin D regulation of a sexually dimorphic asymmetric cell division. Developmental Cell 9, 489-499. [PDF] [PubMed]

126. Kimble, J. and S.L. Crittenden (2005) Germline proliferation and its control (August 15, 2005). WormBook, ed. The C. elegans Research Community, WormBook, doi/10.1895/wormbook.1.13.1, http://www.wormbook.org. [PDF] [PubMed]

125. Bachorik, J.L. and J. Kimble (2005) Redundant control of the Caenorhabditis elegans sperm/oocyte switch by PUF-8 and FBF-1, two distinct PUF RNA-binding proteins. PNAS 102(31), 10893-10897. [PDF] [PubMed]

124. Thompson, B.E., D.S. Bernstein, J.L. Bachorik, A.G. Petcherski, M. Wickens and J. Kimble (2005)  Dose-dependent control of proliferation and sperm specification by FOG-1/CPEB.  Development 132, 3471-3481. [PDF] [PubMed]

123. Kidd III, A.R., J.A. Miskowski, K.R. Siegfried, H. Sawa and J. Kimble (2005) A β-catenin identified by functional rather than sequence criteria and its role in Wnt/MAPK signaling. Cell 121, 761-772. [PDF] [PubMed]

122. Hesselson, D., C. Newman, K.W. Kim and J. Kimble (2004)  GON-1 and fibulin have antagonistic roles in control of organ shape.  Current Biology 14(22), 2005-2010. [PDF] [PubMed]

121. Lamont, L.B., S.L. Crittenden, D. Bernstein, M. Wickens and J. Kimble (2004)  FBF-1 and FBF-2 regulate the size of the mitotic region in the C. elegans germline.  Developmental Cell 7(5), 697-707. [PDF] [PubMed]

120. Eckmann, C.R., S.L. Crittenden, N. Suh and J. Kimble (2004)  GLD-3 and control of the mitosis/meiosis decision in the germline of Caenorhabditis elegans. Genetics 168(1), 147-160. [PDF] [PubMed]

119. Wang L., J. Kimble and M. Wickens (2004)  Tissue-specific modification of gld-2 mRNA in C. elegans: Likely C-to-U editing. RNA 10, 1444-1448. [PDF] [PubMed]

118. Mathies, L.D., M. Schvarzstein, K.M. Morphy, R. Blelloch, A.M. Spence and J. Kimble (2004)  tra-1/GLI controls development of somatic gonadal precursors in C. elegans. Development 131, 4333-4343. [PDF] [PubMed]

117. Kwak, J.E., L. Wang, S. Ballantyne, J. Kimble and M. Wickens (2004) Mammalian GLD-2 homologs are poly(A) polymerases. PNAS 101(13):4407-12. [PDF] [PubMed]

116. Chang, W., C. Tilmann, K. Thoemke, F.H. Markussen, L.D. Mathies, J. Kimble and D. Zarkower (2004) A forkhead protein controls sexual identity of the C. elegans male somatic gonad. Development 131(6):1425-36. [PDF] [PubMed]

115. Siegfried, K.R., A.R. Kidd 3rd, M.A. Chesney and J. Kimble (2004) The sys-1 and sys-3 genes cooperate with Wnt signaling to establish the proximal-distal axis of the Caenorhabditis elegans gonad. Genetics 166(1):171-86. [PDF] [PubMed]

114. Crittenden, S.L., C.R. Eckmann, L. Wang, D.S. Bernstein, M. Wickens and J. Kimble (2003) Regulation of the mitosis/meiosis decision in the Caenorhabditis elegans germline. Philosophical Transactions of the Royal Society of London B 358, 1359-1362. [PDF] [PubMed]

113. Mathies L.D., S.T. Henderson, and J. Kimble (2003) The C. elegans Hand gene controls embryogenesis and early gonadogenesis. Development 130(13), 2881-92. [PDF] [PubMed]

112. Haag, E.S., S. Wang and J. Kimble (2002)  Rapid coevolution of the nematode sex-determining genes fem-3 and tra-2. Current Biology 12, 2035-2041. [PDF] [PubMed]

111. Eckmann, C.R., B. Kraemer, M. Wickens and J. Kimble (2002)  GLD-3, a Bicaudal-C homolog that represses FBF to control germline sex determination in C. elegansDevelopmental Cell 3(5), 697-710. [PDF] [PubMed]

110. Wang, L., C.R. Eckmann, L.C. Kadyk, M. Wickens, and J. Kimble (2002) A regulatory cytoplasmic poly(A) polymerase in Caenorhabditis elegans. Nature 419, 312-316. [PDF] [PubMed]

109. Rudel, D. and J. Kimble (2002)  Evolution of discrete Notch-like receptors from a distant gene duplication in CaenorhabditisEvolution and Development 4(5), 319-333. [PDF] [PubMed]

108. Crittenden, S.L., D.S. Bernstein, J.L. Bachorik, B.E. Thompson, M. Gallegos, A.G. Petcherski, G. Moulder, R. Barstead, M. Wickens and J. Kimble (2002) A conserved RNA-binding protein controls germline stem cells in Caenorhabditis elegans. Nature 417, 660-663. [PDF] [PubMed]

107. Belfiore, M., L.D. Mathies, P. Pugnale, G. Moulder, R. Barstead, J. Kimble, and A. Puoti (2002) The MEP-1 zinc-finger protein acts with MOG DEAH box proteins to control gene expression via the fem-3 3' untranslated region in Caenorhabditis elegans. RNA 8(6), 725-739. [PDF] [PubMed]

106. Wickens, M., D.S. Bernstein, J. Kimble and R. Parker (2002) A PUF family portrait: 3'UTR regulation as a way of life. Trends in Genetics 18(3), 150-157. [PDF] [PubMed]

105. Siegfried, K. and J. Kimble (2002) POP-1 controls axis formation during early gonadogenesis in C. elegans. Development 129(2), 443-453. [PDF] [PubMed]

104. Wickens, M., D.S. Bernstein, S.L. Crittenden, C. Luitjens and J. Kimble (2001) PUF proteins and 3'UTR regulation in the Caenorhabditis elegans germ line. Cold Spring Harbor Symposia on Quantitative Biology LXVI, 337-343. [PDF]

103. Wang, S. and J. Kimble (2001) The TRA-1 transcription factor binds TRA-2 to regulate sexual fates in Caenorhabditis elegans. The EMBO Journal 20(6), 1363-1372. [PDF] [PubMed]

102. Kimble, J. (2001) The 2000 George W. Beadle Medal. John Sulston and Robert Waterston. Genetics 157, 467-468. [PDF]

101. Rudel, D. and J. Kimble (2001) Conservation of glp-1 regulation and function in nematodes. Genetics 157, 639-654. [PDF] [PubMed]

100. Miskowski, J., Y. Li and J. Kimble (2001) The sys-1 gene and sexual dimorphism during gonadogenesis in Caenorhabditis elegans. Developmental Biology 230, 61-73. [PDF] [PubMed]

99. Jin, S.W., J. Kimble and R.E. Ellis (2001) Regulation of cell fate in Caenorhabditis elegans by a novel cytoplasmic polyadenylation element binding protein. Developmental Biology 229, 537-553. [PDF] [PubMed]

98. Friedman, L.C., S. Santa Anna-Arriola, J. Hodgkin and J. Kimble (2000) gon-4, a cell lineage regulator required for gonadogenesis in Caenorhabditis elegans. Developmental Biology 228, 350-362. [PDF] [PubMed]

97. Luitjens, C., M. Gallegos, B. Kraemer, J. Kimble and M. Wickens (2000) CPEB proteins control two key steps in spermatogenesis in C. elegans. Genes & Development 14, 2596-2609. [PDF] [PubMed]

96. Wickens, M., E.B. Goodwin, J. Kimble, S. Strickland and M.W. Hentze (2000) Translational control of developmental decisions. In Translational Control of Gene Expression. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY. pp. 295-370. [PDF]

95. Huang, K., K.D. Johnson, A.G. Petcherski, T. Vandergon, E.A. Mosser, N.G. Copeland, N.A. Jenkins, J. Kimble and E.H. Bresnick (2000) A HECT domain ubiquitin ligase closely related to the mammalian protein WWP1 is essential for Caenorhabditis elegans embryogenesis. Gene 252(1-2), 137-145. [PDF] [PubMed]

94. Petcherski, A.G. and J. Kimble (2000) Mastermind is a putative activator for Notch. Current Biology 10(13), R471-R473. [PDF] [PubMed]

93. Petcherski, A.G. and J. Kimble (2000) LAG-3 is a putative transcriptional activator in the C. elegans pathway. Nature 405, 364-368. [PDF] [PubMed]

92. Haag, E. and J. Kimble (2000) Regulatory elements required for development of Caenorhabditis elegans hermaphrodites are conserved in the tra-2 homologue of C. remanei, a male/female sister species. Genetics 155(1), 105-116. [PDF] [PubMed]

91. Friedman, L.C., J.J. Higgin, G. Moulder, R. Barstead, R.T. Raines and J. Kimble (2000) Prolyl 4-hydroxylase is required for viability and morphogenesis in Caenorhabditis elegans. PNAS 97, 4736-4741. [PDF] [PubMed]

90. Puoti, A. and J. Kimble (2000) The hermaphrodite sperm/oocyte switch requires the Caenorhabditis elegans homologs of PRP2 and PRP22. PNAS 97(7), 3276-3281. [PDF] [PubMed]

89. Chen, P.-J., A. Singal, J. Kimble and R.E. Ellis (2000) A novel member of the Tob family of proteins controls sexual fate in Caenorhabditis elegans germ cells. Developmental Biology 217, 77-90. [PDF] [PubMed]

88. Blelloch, R, S. Santa Anna-Arriola, D. Gao, Y. Li, J. Hodgkin and J. Kimble (1999) The gon-1 gene is required for gonadal morphogenesis in Caenorhabditis elegans. Developmental Biology 216, 382-393. [PDF] [PubMed]

87. Blelloch, R., C. Newman and J. Kimble (1999) Control of cell migration during Caenorhabditis elegans development. Current Opinion in Cell Biology 11, 608-613. [PDF] [PubMed]

86. Kraemer, B., S.L. Crittenden, M. Gallegos, G. Moulder, R. Barstead, J. Kimble and M. Wickens (1999) NANOS-3 and FBF proteins physically interact to control the sperm?oocyte switch in Caenorhabditis elegans. Current Biology 9(18), 1009-1018. [PDF] [PubMed]

85. Blelloch, R. and J. Kimble (1999) Control of organ shape by a secreted metalloprotease in the nematode Caenorhabditis elegans. Nature 399, 586-590. [PDF] [PubMed]

84. Puoti, A. and J. Kimble (1999) The Caenorhabditis elegans sex determination gene mog-1 encodes a member of the DEAH-box protein family. Molecular and Cellular Biology 19(3), 2189-2197. [PDF] [PubMed]

83. Crittenden, S.L. and J. Kimble (1999) Confocal methods for Caenorhabditis elegans. In Methods in Molecular Biology, vol. 122: Confocal Microscopy Methods and Protocols (S. Paddock, ed.) Totowa, NJ: Humana Press Inc. pp. 141-151. [PDF] [PubMed]

82. Hodgkin, J., H.R. Horvitz, B.R. Jasny and J. Kimble (1998) C. elegans: Sequence to biology. Science 282, 2011. [PDF] Summary

81. Gallegos, M., J. Ahringer, S. Crittenden and J. Kimble (1998) Repression by the 3? UTR of fem-3, a sex-determining gene, relies on a ubiquitous mog-dependent control in Caenorhabditis elegans. The EMBO Journal 17(21), 6337-6347. [PDF] [PubMed]

80. Kuwabara, P.E., P.G. Okkema and J. Kimble (1998) Germ-line regulation of the Caenorhabditis elegans sex-determining gene tra-2. Developmental Biology 204, 251-262. [PDF] [PubMed]

79. Kimble, J., S. Henderson and S. Crittenden (1998) Notch/LIN-12 signaling: transduction by regulated protein slicing. Trends in Biochemical Sciences 23(9), 353-357. [PDF] [PubMed]

78. Horner, M.A., S. Quintin, M.E. Domeier, J. Kimble, M. Labouesse, and S.E. Mango (1998) pha-4, an HNF-3 homolog, specifies pharyngeal organ identity in Caenorhabditis elegans. Genes and Development 12, 1947-1952. [PDF] [PubMed]

77. Kadyk, L.C. and J. Kimble (1998) Genetic regulation of entry into meiosis in Caenorhabditis elegans. Development 125, 1803-1813. [PDF] [PubMed]

76. Crittenden, S.L. and J. Kimble (1998) Immunofluorescence methods for C. elegans. In: Cells: A Laboratory Manual (David L. Spector, Robert D. Goldman and Leslie A. Leinwand, eds.). Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press. pp. 108.1-108.9. [PDF]

75. Zhang, B., M. Gallegos, A. Puoti, E. Durkin, S. Fields, J. Kimble and M.P. Wickens (1997) A conserved RNA-binding protein that regulates sexual fates in the C. elegans hermaphrodite germ line. Nature 390, 477-484. [PDF] [PubMed]

74. Puoti, A., M. Gallegos, B. Zhang, M.P. Wickens and J. Kimble (1997) Controls of cell fate and pattern by 3? untranslated regions: the Caenorhabditis elegans sperm/oocyte decision. Cold Spring Harbor Symposia on Quantitative Biology, Volume LXII, 19-24. [PDF] [PubMed]

73. Kimble, J. and P. Simpson (1997) The LIN-12/Notch signaling pathway and its regulation. Annual Review of Cell and Developmental Biology 13, 333-361. [PDF] [PubMed]

72. Henderson, S.T., D. Gao, S. Christensen and J. Kimble (1997) Functional domains of LAG-2, a putative signaling ligand for LIN-12 and GLP-1 receptors in Caenorhabditis elegans. Molecular Biology of the Cell 8, 1751-1762. [PDF] [PubMed]

71. Panganiban, G., S.M. Irvine, C. Lowe, H. Roehl, L.S. Corley, B. Sherbon, J.K. Grenier, J.F. Fallon, J. Kimble, M. Walker, G.A. Wray, B.J. Swalla, M.Q. Martindale and S.B. Carroll (1997) The origin and evolution of animal appendages. PNAS USA 94, 5162-5166. [PDF] [PubMed]

70. Goodwin, E.B., K. Hofstra, C.A. Hurney, S. Mango and J. Kimble (1997) A genetic pathway for regulation of tra-2 translation. Development 124, 749-758. [PDF] [PubMed]

69. Anderson, P. and J. Kimble (1997) mRNA and translation. In: C. elega ns II. Edited by D.L. Riddle, T. Blumenthal, B.J. Meyer, and J.R. Priess. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York. pp. 185-208. [ PDF]

68. Kadyk, L.C., E.J. Lambie and J. Kimble (1997) glp-3 is required for mitosis and meiosis in the Caenorhabditis elegans germ line. Genetics 145, 111-121. [PDF] [PubMed]

67. Crittenden, S.L., D. Rudel, J. Binder, T.C. Evans and J. Kimble (1997) Genes required for GLP-1 asymmetry in the early Caenorhabditis elegans embryo. Developmental Biology 181, 36-46. [PDF] [PubMed]

66. Roehl, H., M. Bosenberg, R. Blelloch and J. Kimble (1996) Roles of the RAM and ANK domains in signaling by the C. elegans GLP-1 receptor. The EMBO Journal 15, 7002-7012. [PDF] [PubMed]

65. Kimble, J. and J.C. Smith (1996) Pattern formation and developmental mechanisms. Editorial overview. Current Opinion in Genetics & Development 6, 391-394. [PDF] [PubMed]

64. Christensen, S., V. Kodoyianni, M. Bosenberg, L. Friedman and J. Kimble (1996) lag-1, a gene required for lin-12 and glp-1 signaling in Caenorhabditis elegans, is homologous to human CBF1 and Drosophila Su(H). Development 122, 1373-1383. [PDF] [PubMed]

63. Wickens, M., J. Kimble and S. Strickland (1996) Translational control of developmental decisions. In: Translational Control (J.W.B. Hershey, M.B. Mathews and N. Sonenberg, eds.). CSHLP Monograph 30. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press. pp. 411-450. [PDF]

62. Gao, D. and J. Kimble (1995) APX-1 can substitute for its homolog LAG-2 to direct cell interactions throughout Caenorhabditis elegans development. PNAS USA 92, 9839-9842. [PDF] [PubMed]

61. Kuwabara, P.E. and J. Kimble (1995) A predicted membrane protein, TRA-2A, directs hermaphrodite development in Caenorhabditis elegans. Development 121, 2995-3004. [PDF] [PubMed]

60. Francis, R., M.K. Barton, J. Kimble and T. Schedl (1995) gld-1, a tumor suppressor gene required for oocyte development in Caenorhabditis elegans. Genetics 139, 579-606. [PDF] [PubMed]

59. Ellis, R.E. and J. Kimble (1995) The fog-3 gene and regulation of cell fate in the germ line of Caenorhabditis elegans. Genetics 139, 561-577. [PDF] [PubMed]

58. Kimble, J. (1994) An ancient molecular mechanism for establishing embryonic polarity? Science 266, 577-578. [PDF] [PubMed]

57. Mango, S.E., E.J. Lambie and J. Kimble (1994) The pha-4 gene is required to generate the pharyngeal primordium of Caenorhabditis elegans. Development 120, 3019-3031. [PDF] [PubMed]

56. Henderson, S.T., D. Gao, E.J. Lambie and J. Kimble (1994) lag-2 may encode a signaling ligand for the GLP-1 and LIN-12 receptors of C. elegans. Development 120, 2913-2924. [PDF] [PubMed]

55. Crittenden, S.L., E.R. Troemel, T.C. Evans and J. Kimble (1994) GLP-1 is localized to the mitotic region of the C. elegans germ line. Development 120, 2901-2911. [PDF] [PubMed]

54. Evans, T.C., S.L. Crittenden, V. Kodoyianni and J. Kimble (1994) Translational control of maternal glp-1 mRNA establishes an asymmetry in the C. elegans embryo. Cell 77, 183-194. [PDF] [PubMed]

53. Ellis, R.E. and J. Kimble (1994) Control of germ cell differentiation in Caenorhabditis elegans. In: Germline Development, eds. J. Marsh and J. Goode. Chichester: John Wiley & Sons. CIBA Foundation Symposium 182, 179-192. [PDF] [PubMed]

52. Graham, P.L., T. Schedl and J. Kimble (1993) More mog genes that influence the switch from spermatogenesis to oogenesis in the hermaphrodite germ line of Caenorhabditis elegans. Developmental Genetics 14, 471-484. [PDF] [PubMed]

51. Maine, E.M. and J. Kimble (1993) Suppressors of glp-1, a gene required for cell communication during development in Caenorhabditis elegans, define a set of interacting genes. Genetics 135, 1011-1022. [PDF] [PubMed]

50. Goodwin, E.B., P.G. Okkema, T.C. Evans and J. Kimble (1993) Translational regulation of tra-2 by its 3' untranslated region controls sexual identity in C. elegans. Cell 75, 329-339. [PDF] [PubMed]

49. Roehl, H. and J. Kimble (1993) Control of cell fate in C. elegans by a GLP-1 peptide consisting primarily of ankyrin repeats. Nature 364, 632-635. [PDF] [PubMed]

48. Graham, P.L. and J. Kimble (1993) The mog-1 gene is required for the switch from spermatogenesis to oogenesis in Caenorhabditis elegans. Genetics 133, 919-931. [PDF] [PubMed]

47. Kimble, J., S. Crittenden, E. Lambie, V. Kodoyianni, S. Mango and E. Troemel (1992) Regulation of induction by GLP1, a localized cell surface receptor in Caenorhabditis elegans. Cold Spring Harbor Symposia on Quantitative Biology LVII, 401-407. [PDF] [PubMed]

46. Evans, T.C., E.B. Goodwin and J. Kimble (1992) Translational regulation of development and maternal RNAs in Caenorhabditis elegans. Seminars in Developmental Biology 3, 381-389. [PDF]

45. Kodoyianni, V., E.M. Maine and J. Kimble (1992) Molecular basis of loss-of-function mutations in the glp-1 gene of Caenorhabditis elegans. Molecular Biology of the Cell 3, 1199-1213. [PDF] [PubMed]

44. Kuwabara, P.E. and J. Kimble (1992) Sex determination in Caenorhabditis elegans. Journal of Nematology 24(3), 324-329. [PDF]

43. Kuwabara, P.E., P.G. Okkema and J. Kimble (1992) tra-2 encodes a membrane protein and may mediate cell communication in the Caenorhabditis elegans sex determination pathway. Molecular Biology of the Cell 3, 461-473. [PDF] [PubMed]

42. Ahringer, J., T.A. Rosenquist, D.N. Lawson and J. Kimble (1992) The Caenorhabditis elegans sex-determining gene fem-3 is regulated post-transcriptionally. The EMBO Journal 11, 2303-2310. [PDF] [PubMed]

41. Kuwabara, P. and J. Kimble (1992) Molecular genetics of sex determination in C. elegans. Trends in Genetics 8, 164-168. [PDF] [PubMed]

40. Lambie, E.J. and J. Kimble (1991) Genetic control of cell interactions in nematode development. Annual Review of Genetics 25, 411-436. [PDF] [PubMed]

39. Lambie, E.J. and J. Kimble (1991) lin-12 and glp-1: homologous genes with overlapping functions in Caenorhabditis elegans. In: Cell-Cell Interactions in Early Development, ed. J. Gerhart. 49th Annual Symposium of the Society for Developmental Biology. New York: Wiley-Liss, Inc., pp. 283-296. [PDF]

38. Mango, S.E., E.M. Maine and J. Kimble (1991) Carboxy-terminal truncation activates glp-1 protein to specify vulval fates in Caenorhabditis elegans. Nature 352, 811-815. [PDF] [PubMed]

37. Lambie, E.J. and J. Kimble. (1991) Two homologous regulatory genes, lin-12 and glp-1, have overlapping functions. Development 112, 231-240. [PDF] [PubMed]

36. Ahringer, J. and J. Kimble (1991) Control of the sperm-oocyte switch in Caenorhabditis elegans hermaphrodites by the fem-3 3? untranslated region. Nature 349, 346-348. [PDF] [PubMed]

35. Okkema, P.G. and J. Kimble (1991) Molecular analysis of tra-2, a sex-determining gene in C. elegans. The EMBO Journal 10, 171-176. [PDF] [PubMed]

34. Rosenquist, T., J. Ahringer, M.K. Barton, P. Graham, P. Okkema and J. Kimble (1990) Genetic control of sex determination in the hermaphrodite germ line of Caenorhabditis elegans. In: Genetics of Pattern Formation and Growth Control, ed. A.P. Mahowald. 48th Annual Symposium of the Society for Developmental Biology. New York: Wiley-Liss, Inc., pp. 91-102. [PDF]

33. Barton, M.K. and J. Kimble (1990) fog-1, a regulatory gene required for specification of spermatogenesis in the germ line of Caenorhabditis elegans. Genetics 125, 29-39. [PDF] [PubMed]

32. Maine, E.M. and J. Kimble (1990) Genetic control of cell communication in C. elegans development. BioEssays 12, 265-271. [PDF] [PubMed]

31. Austin, J., E.M. Maine and J. Kimble (1989) Genetics of intercellular signalling in C. elegans. In: The Molecular Basis of Positional Signalling, British Society for Developmental Biology Symposium. Development 1989 Supplement, 53-57. [PDF] [PubMed]

30. Schedl, T., P.L. Graham, M.K. Barton and J. Kimble (1989) Analysis of the role of tra-1 in germline sex determination in the nematode Caenorhabditis elegans. Genetics 123, 755-769. [PDF] [PubMed]

29. Austin, J. and J. Kimble (1989) Transcript analysis of glp-1 and lin-12, homologous genes required for cell interactions during development of C. elegans. Cell 58, 565-571. [PDF] [PubMed]

28. Kimble, J. and J. Austin. (1989) Genetic control of cellular interactions in Caenorhabditis elegans development. In: Cellular Basis of Morphogenesis, CIBA Foundation Symposium 144. Chichester, Wiley, pp. 212-226. [PDF] [PubMed]

27. Maine, E.M. and J. Kimble (1989) Identification of genes that interact with glp-1, a gene required for inductive cell interactions in Caenorhabditis elegans. Development 105, 133-143. [PDF] [PubMed]

26. Kimble, J. (1988) Genetic control of sex determination in the germ line of Caenorhabditis elegans. Philosophical Transactions of the Royal Society of London B. 322, 11-18. [PDF] [PubMed]

25. Rosenquist, T.A. and J. Kimble (1988) Molecular cloning and transcript analysis of fem-3, a sex-determination gene in Caenorhabditis elegans. Genes and Development 2, 606-616. [PDF] [PubMed]

24. Schedl, T. and J. Kimble (1988) fog-2, a germ-line-specific sex determination gene required for hermaphrodite spermatogenesis in Caenorhabditis elegans. Genetics 119, 43-61. [PDF] [PubMed]

23. Sulston, J., H.R. Horvitz and J. Kimble (1988) Appendix 3. Cell Lineage. In: The nematode Caenorhabditis elegans, ed. W.B. Wood. Cold Spring Harbor Laboratory Press, pp.457-489. [PDF]

22. Kimble, J. and S. Ward (1988) Germ-line development and fertilization. In: The nematode Caenorhabditis elegans, ed. W.B. Wood. Cold Spring Harbor Laboratory Press, pp. 191-213. [PDF]

21. Kimble, J. and T. Schedl (1988) Developmental Genetics of Caenorhabditis elegans. In: Developmental Genetics of Higher Organisms: A Primer in Developmental Biology. ed. G.M. Malacinski. New York, Macmillan Publishing Company. pp. 171-192. [PDF]

20. Austin, J. and J. Kimble (1987) glp-1 is required in the germ line for regulation of the decision between mitosis and meiosis in C. elegans. Cell 51, 589-599. [PDF] [PubMed]

19. Kimble, J. (1987) Genetic control of sex determination in the germ line of C. elegans. In: Results and Problems in Cell Differentiation, ed. Hennig, W., Springer-Verlag, Berlin. [PDF] [PubMed]

18. Anderson, P. and J. Kimble (1987) Genetics of development elucidated by nematodes. Nature 328, 202. [PDF] [PubMed]

17. Barton, M.K., T.B. Schedl and J. Kimble (1987) Gain-of-function mutations of fem-3, a sex determination gene in Caenorhabditis elegans. Genetics 115, 107-119. [PDF] [PubMed]

16. Kimble, J., M.K. Barton, T.B. Schedl, T.A. Rosenquist and J. Austin (1986) Controls of postembryonic germ line development in Caenorhabditis elegans. In: Gametogenesis and the Early Embryo, ed. J.G. Gall. 44th Annual Symposium of the Society for Developmental Biology. New York: Alan R. Liss, Inc. pp. 97-110. [PDF]

15. Kimble, J., Edgar, L., and D. Hirsh (1984) Specification of male development in Caenorhabditis elegans: the fem genes. Developmental Biology 105, 234-239. [PDF] [PubMed]

14. Kimble, J. (1983) Germ cell development in Caenorhabditis elegans: A brief review. In: Current Problems in Germ Cell Differentiation, eds. A. McLaren and C.C. Wylie, British Society for Development Biology 7, 241-255. [PDF]

13. Kimble, J. and W.J. Sharrock (1983) Tissue-specific synthesis of yolk proteins in Caenorhabditis elegans. Developmental Biology 96, 189-196. [PDF] [PubMed]

12. Kimble, J., J. Hodgkin, T. Smith and J. Smith (1982) Suppression of an amber mutation by microinjection of suppressor tRNA in C. elegans. Nature 299, 456-458. [PDF] [PubMed]

11. Kimble, J.E. (1981) Strategies for control of pattern formation in Caenorhabditis elegans. Philosophical Transactions of the Royal Society of London B 295, 539-551. [PDF] [PubMed]

10. Kimble, J. (1981) Alterations in cell lineage following laser ablation of cells in the somatic gonad of Caenorhabditis elegans. Developmental Biology 87, 286-300. [PDF] [PubMed]

9. Kimble, J.E. and J.G. White (1981) On the control of germ cell development in Caenorhabditis elegans. Developmental Biology 81, 208-219. [PDF] [PubMed]

8. Kimble, J., Sulston, J. and J. White (1979) Regulative development in the post-embryonic lineages of Caenorhabditis elegans. In: Cell Lineage, Stem Cells and Cell Determination, eds. N. Le Douarin and A. Monroy. INSERM Symposium No. 10. Elsevier/North-Holland Biomedical Press, pp. 59-68. [PDF]

7. Kimble, J. and D. Hirsh (1979) The postembryonic cell lineages of the hermaphrodite and male gonads in Caenorhabditis elegans. Developmental Biology 70, 396-417. [PDF] [PubMed]

6. Kimble, J. (1978) Post-embryonic cell lineage of the hermaphrodite and male gonads in Caenorhabditis elegans. University of Colorado, Ph.D. Thesis.

5. Kimble, J.E. and K. Mollgaard (1975) Subcommissural organ-associated neurons in fetal and neonatal rabbit. Cell and Tissue Research 159, 195-204. [PubMed]

4. Moller, M., K. Mollgaard and J.E. Kimble (1975) Presence of a pineal nerve in sheep and rabbit fetuses. Cell and Tissue Research 158, 451-459. [PubMed]

3. Mollgaard, K., M. Moller and J. Kimble (1973) Histochemical investigations on the human fetal subcommissural organ. II. The "Large Granules". Histochemie 37, 61-74. [PubMed]

2. Kimble, J.E. and K. Mollgaard (1973) Evidence for basal secretion in the subcommissural organ of the adult rabbit. Z Zellforsch Mikrosk Anat. 42, 223-239. [PubMed]

1. Kimble, J.E., S.C. Sorensen and K. Mollgaard (1973) Cell junctions in the subcommissural organ of the rabbit as revealed by the use of ruthenium red. Z Zellforsch Mikrosk Anat. 137, 375-386. [PubMed]