Katherine Henzler-Wildman

Photo of Katherine Henzler-Wildman
Associate Professor
Ph.D. in Chemistry, University of Michigan
Phone: (608) 890-1094
Email: henzlerwildm@wisc.edu

Publications

25. Lee W., Cornilescu G., Dashti H., Eghbalnia H.R., Tonelli M., Westler W.M., Butcher S.E., Henzler-Wildman K.A., Markley J.L. (2016) "Integrative NMR for biomolecular research." 64, 307-332. PMID: 27023095 [PubMed]

24. Brettmann J.B., Urusova D., Tonelli M., Silva J.R., Henzler-Wildman K.A. (2015) "Role of protein dynamics in ion selectivity and allosteric coupling in the NaK channel." Proc Natl Acad Sci USA. 112, 15366-15371. PMID: 26621745 [PubMed]

23. Morrison E.A., Robinson A.E., Liu Y., Henzler-Wildman K.A. (2015) "Asymmetric protonation of EmrE." J Gen Physiol. 146, 445-461. PMID: 26573622 [PubMed]

22. Dutta S., Morrison E.A., Henzler-Wildman K.A. (2014) "Blocking dynamics of the SMR transporter EmrE impairs efflux activity." Biophys J. 107, 613-620. PMID: 25099800 [PubMed]

21. Dutta S., Morrison E.A., Henzler-Wildman K.A. (2014) "EmrE dimerization depends on membrane environment." Biochim Biophys Acta. 1838, 1817-1822. PMID: 24680655 [PubMed]

20. Morrison E.A., Henzler-Wildman K.A. (2014)"Transported substrate determines exchange rate in the multidrug resistance transporter EmrE." J Biol Chem. 289, 6825-6836. PMID: 24448799 [PubMed]

19. Batchelor J.D., Malpede B.M., Omattage N.S., DeKoster G.T., Henzler-Wildman K.A., Tolia N.H. (2014) "Red blood cell invasion by Plasmodium vivax: structural basis for DBP engagement of DARC." PLoS Pathog. 10, e1003869.
PMID:24415938 [PubMed]

18. Gonzalez-Perez, V., Zeng, X.-H., Henzler-Wildman, K. A., Lingle, C. J. (2012) “Stereospecific binding of an intrinsically disordered region of an auxiliary beta subunit mediates BK channel inactivation” Nature. 489, 133-136. PMID: 22522931 [PubMed]

17. Morrison, E. A., Henzler-Wildman, K. A. (2012) “Reconstitution of Integral Membrane Proteins into Isotropic Bicelles with Improved Sample Stability and Expanded Lipid Composition Profile.”  Biochim. Biophys. Acta Biomembranes. 1818, 814-820. PMID: 22226849 [PubMed]

16. Henzler-Wildman, K. A. (2012) “Analyzing Conformational Changes in the Transport Cycle of EmrE.”  Curr. Opin. Struct. Biol. 22, 38-43. PMID: 22100111 [PubMed]

15. Morrison, E. A.*, Dekoster, G. T.*, Dutta, S., Clarkson, M., Vafabkhsh, R., Bahl, A., Kern, D., Ha, T., and Henzler-Wildman, K. A. (2012) “Antiparallel EmrE Exports Drugs by Exchanging Between Asymmetric Structures.”  Nature. 481, 45-50. PMID: 22178925 [PubMed]

14. Ramamoorthy, A., Lee, D. K., Santos, J. S., and Henzler-Wildman, K. A. (2008) “Nitrogen-14 Solid-state NMR Spectroscopy of Aligned Phospholipid Bilayers to Probe Peptide-Lipid Interaction and Oligomerization of Membrane Associated Peptides.”  J. Am. Chem. Soc. 130, 11023-11029. PMID: 18646853 [PubMed]

13. Porcelli, F., Verardi, R., Shi, L., Henzler-Wildman, K. A., Ramamoorthy, A., and Veglia, G. (2008) “NMR Structure of the Cathelicidin-derived Human Antimicrobial Peptide LL-37 in Dodecylphosphocholine Micelles.”  Biochemistry.  47, 5565-5572. PMID: 18439024 [PubMed]

12. Henzler-Wildman, K. A. and Kern, D. (2007) “Dynamic Personalities of Proteins” Nature, 450, 964-972. PMID: 18075575 [PubMed]

11. Henzler-Wildman, K. A.*, Lei, M.*, Thai, V., Karplus, M., and Kern, D. (2007) “A Hierarchy of Timescales in Protein Dynamics Linked to Catalysis” Nature, 450, 913-916. PMID: 18026087 [PubMed]

10. Henzler-Wildman, K. A.*, Thai, V.*, Lei, M.*, Ott, M.*, Wolf-Watz, M., Fenn, T., Pozharski, E., Wilson, M., Petsko, G., Karplus, M., Hübner, C., and Kern, D. (2007) “Intrinsic Motions Along an Enzymatic Reaction Trajectory” Nature, 450, 838-844. PMID: 18026086 [PubMed]

9. Moon, J.-Y., Henzler-Wildman, K. A., and Ramamoorthy, A. (2006) “Expression and Purification of a Recombinant LL-37 from Escherichia coli.”  Biochim. Biphys. Acta.  1758, 1351-1358. PMID: 16542635 [PubMed]

8. Wolf-Watz, M., Thai, V., Henzler-Wildman, K. A., Hadjipavlou, G., Eisenmesser, E. Z., and Kern, D.  (2004) "Linkage Between Dynamics and Catalysis in a Thermophilic-Mesophilic Enzyme Pair"  Nat. Struct. Mol. Biol.  11, 945-949.
PMID: 15334070 [PubMed]

7. Henzler Wildman, K. A., Martinez, G. V., Brown, M. F., and Ramamoorthy, A.  (2004) "Perturbation of the Hydrophobic Core of Lipid Bilayers by the Human Antimicrobial Peptide LL-37" Biochemistry.  43, 8459-8469. PMID: 15222757 [PubMed]

6. Lee, D. K., Henzler Wildman, K. A., and Ramamoorthy, A. (2004) “Solid-State NMR Spectroscopy of Aligned Bilayers at Low Temperatures.”  J. Am. Chem. Soc.  126, 2318-2319. DOI: 10.1021/ja039077o [PubsACS]

5. Henzler Wildman, K. A., Ramamoorthy, A., Wakamiya, T., Yoshikawa, T., Crisma, M., Toniolo, C., and Formaggio, F.  (2004)  "A Study of a Cα,β-didehydroalanine Homo-oligopeptide Series in the Solid-state by 13C Cross-polarization Magic Angle Spinning NMR."  J. Peptide Sci.  10, 336-341. PMID: 15214438 [PubMed]

4. Henzler Wildman, K. A., Lee, D. K. and Ramamoorthy, A.  (2003)  "Mechanism of Lipid Bilayer Disruption by the Human Antimicrobial Peptide LL-37."  Biochemistry.  42, 6545-6558. PMID:12767238 [PubMed]

3. Henzler Wildman, K. A., Wilson, E. E., Lee, D. K., Ramamoorthy, A.  (2003)  "Determination of the Conformation and Stability of Simple Homopolypeptides Using Solid State NMR."  Solid State NMR.  24, 94-109.PMID: 12943907 [PubMed]

2. Hallock, K. J., Henzler Wildman, K. A., Lee, D. K., and Ramamoorthy, A.  (2002)  "An Innovative Procedure Using a Sublimable Solid to Align Lipid Bilayers for Solid-State NMR."  Biophys J.  82, 2499-2503. PMID: 11964237 [PubMed]

1. Henzler Wildman, K. A., Lee, D. K., and Ramamoorthy, A. (2002)  "Determination of α-Helix and β-Sheet Stability in the Solid State:  A Solid-State NMR Investigation of Poly(L-Alanine)."  Biopolymers.  64, 246-254. PMID: 12115132 [PubMed]

*These authors contributed equally to the work.