Katherine Henzler-Wildman

Photo of Katherine Henzler-Wildman
Jean V. Thomas Professor in Biochemistry
Ph.D. in Chemistry, University of Michigan
Phone: (608) 890-1094
Email: henzlerwildm@wisc.edu

Publications

33. Chen H, Deng J, Cui Q, Chanda B, Henzler-Wildman K. (2021) " Mapping temperature-dependent conformational change in the voltage-sensing domain of an engineered heat-activated K+ channel." Proc Natl Acad Sci USA.  118(14):e2017280118. PMID: 33782120 [PubMed]

32. Tonelli M, Rienstra C, Anderson TK, Kirchdoerfer R, Henzler-Wildman K. (2021) "1H, 13C, and 15N backbone and side chain chemical shift assignments of the SARS-CoV-2 non-structural protein 7." Biomol NMR Assign. 15(1):73-77.
PMID: 33219414 [PubMed]

31. Shcherbakov AA, Hisao G, Mandala VS, Thomas NE, Soltani M, Salter EA, Davis JH Jr, Henzler-Wildman KA, Hong M. (2021) "Structure and dynamics of the drug-bound bacterial transporter EmrE in lipid bilayers." Nat Commun. 2(1):172. PMID: 33420032 [PubMed]

30. Hussey GA, Thomas NE, Henzler-Wildman KA. (2020) "Highly coupled transport can be achieved in free-exchange transport models." J Gen Physiol. 152(1). pii: e201912437. PMID: 31816638 [PubMed]

29. Chen H, Pan J, Gandhi DM, Dockendorff C, Cui Q, Chanda B, Henzler-Wildman KA. (2019) "NMR Structural Analysis of Isolated Shaker Voltage-Sensing Domain in LPPG Micelles." Biophys J. 117(2):388-398. PMID: 31301804 [PubMed]

28. Wu C, Wynne SA, Thomas NE, Uhlemann EM, Tate CG, Henzler-Wildman KA. (2019) "Identification of an Alternating-Access Dynamics Mutant of EmrE with Impaired Transport." J Mol Biol. 431(15):2777-2789. PMID: 31158365 [PubMed]

27. Thomas NE, Wu C, Morrison EA, Robinson AE, Werner JP, Henzler-Wildman KA. (2018) "The C terminus of the bacterial multidrug transporter EmrE couples drug binding to proton release." J Biol Chem. Dec 7;293(49):19137-19147.
PMID: 30287687 [PubMed]

26. Robinson A.E., Thomas N.E., Morrison E.A., Balthazor B.M., Henzler-Wildman K.A. (2017) "New free-exchange model of EmrE transport." Proc Natl Acad Sci USA. 114, E10083-E10091. PMID: 29114048 [PubMed]

25. Lee W., Cornilescu G., Dashti H., Eghbalnia H.R., Tonelli M., Westler W.M., Butcher S.E., Henzler-Wildman K.A., Markley J.L. (2016) "Integrative NMR for biomolecular research." J Biomol NMR. 64, 307-332. PMID: 27023095 [PubMed]

24. Brettmann J.B., Urusova D., Tonelli M., Silva J.R., Henzler-Wildman K.A. (2015) "Role of protein dynamics in ion selectivity and allosteric coupling in the NaK channel." Proc Natl Acad Sci USA. 112, 15366-15371. PMID: 26621745 [PubMed]

23. Morrison E.A., Robinson A.E., Liu Y., Henzler-Wildman K.A. (2015) "Asymmetric protonation of EmrE." J Gen Physiol. 146, 445-461. PMID: 26573622 [PubMed]

22. Dutta S., Morrison E.A., Henzler-Wildman K.A. (2014) "Blocking dynamics of the SMR transporter EmrE impairs efflux activity." Biophys J. 107, 613-620. PMID: 25099800 [PubMed]

21. Dutta S., Morrison E.A., Henzler-Wildman K.A. (2014) "EmrE dimerization depends on membrane environment." Biochim Biophys Acta. 1838, 1817-1822. PMID: 24680655 [PubMed]

20. Morrison E.A., Henzler-Wildman K.A. (2014)"Transported substrate determines exchange rate in the multidrug resistance transporter EmrE." J Biol Chem. 289, 6825-6836. PMID: 24448799 [PubMed]

19. Batchelor J.D., Malpede B.M., Omattage N.S., DeKoster G.T., Henzler-Wildman K.A., Tolia N.H. (2014) "Red blood cell invasion by Plasmodium vivax: structural basis for DBP engagement of DARC." PLoS Pathog. 10, e1003869.
PMID:24415938 [PubMed]

18. Gonzalez-Perez, V., Zeng, X.-H., Henzler-Wildman, K. A., Lingle, C. J. (2012) “Stereospecific binding of an intrinsically disordered region of an auxiliary beta subunit mediates BK channel inactivation” Nature. 489, 133-136. PMID: 22522931 [PubMed]

17. Morrison, E. A., Henzler-Wildman, K. A. (2012) “Reconstitution of Integral Membrane Proteins into Isotropic Bicelles with Improved Sample Stability and Expanded Lipid Composition Profile.”  Biochim. Biophys. Acta Biomembranes. 1818, 814-820. PMID: 22226849 [PubMed]

16. Henzler-Wildman, K. A. (2012) “Analyzing Conformational Changes in the Transport Cycle of EmrE.”  Curr. Opin. Struct. Biol. 22, 38-43. PMID: 22100111 [PubMed]

15. Morrison, E. A.*, Dekoster, G. T.*, Dutta, S., Clarkson, M., Vafabkhsh, R., Bahl, A., Kern, D., Ha, T., and Henzler-Wildman, K. A. (2012) “Antiparallel EmrE Exports Drugs by Exchanging Between Asymmetric Structures.”  Nature. 481, 45-50. PMID: 22178925 [PubMed]

14. Ramamoorthy, A., Lee, D. K., Santos, J. S., and Henzler-Wildman, K. A. (2008) “Nitrogen-14 Solid-state NMR Spectroscopy of Aligned Phospholipid Bilayers to Probe Peptide-Lipid Interaction and Oligomerization of Membrane Associated Peptides.”  J. Am. Chem. Soc. 130, 11023-11029. PMID: 18646853 [PubMed]

13. Porcelli, F., Verardi, R., Shi, L., Henzler-Wildman, K. A., Ramamoorthy, A., and Veglia, G. (2008) “NMR Structure of the Cathelicidin-derived Human Antimicrobial Peptide LL-37 in Dodecylphosphocholine Micelles.”  Biochemistry.  47, 5565-5572. PMID: 18439024 [PubMed]

12. Henzler-Wildman, K. A. and Kern, D. (2007) “Dynamic Personalities of Proteins” Nature, 450, 964-972. PMID: 18075575 [PubMed]

11. Henzler-Wildman, K. A.*, Lei, M.*, Thai, V., Karplus, M., and Kern, D. (2007) “A Hierarchy of Timescales in Protein Dynamics Linked to Catalysis” Nature, 450, 913-916. PMID: 18026087 [PubMed]

10. Henzler-Wildman, K. A.*, Thai, V.*, Lei, M.*, Ott, M.*, Wolf-Watz, M., Fenn, T., Pozharski, E., Wilson, M., Petsko, G., Karplus, M., Hübner, C., and Kern, D. (2007) “Intrinsic Motions Along an Enzymatic Reaction Trajectory” Nature, 450, 838-844. PMID: 18026086 [PubMed]

9. Moon, J.-Y., Henzler-Wildman, K. A., and Ramamoorthy, A. (2006) “Expression and Purification of a Recombinant LL-37 from Escherichia coli.”  Biochim. Biphys. Acta.  1758, 1351-1358. PMID: 16542635 [PubMed]

8. Wolf-Watz, M., Thai, V., Henzler-Wildman, K. A., Hadjipavlou, G., Eisenmesser, E. Z., and Kern, D.  (2004) "Linkage Between Dynamics and Catalysis in a Thermophilic-Mesophilic Enzyme Pair"  Nat. Struct. Mol. Biol.  11, 945-949.
PMID: 15334070 [PubMed]

7. Henzler Wildman, K. A., Martinez, G. V., Brown, M. F., and Ramamoorthy, A.  (2004) "Perturbation of the Hydrophobic Core of Lipid Bilayers by the Human Antimicrobial Peptide LL-37" Biochemistry.  43, 8459-8469. PMID: 15222757 [PubMed]

6. Lee, D. K., Henzler Wildman, K. A., and Ramamoorthy, A. (2004) “Solid-State NMR Spectroscopy of Aligned Bilayers at Low Temperatures.”  J. Am. Chem. Soc.  126, 2318-2319. DOI: 10.1021/ja039077o [PubsACS]

5. Henzler Wildman, K. A., Ramamoorthy, A., Wakamiya, T., Yoshikawa, T., Crisma, M., Toniolo, C., and Formaggio, F.  (2004)  "A Study of a Cα,β-didehydroalanine Homo-oligopeptide Series in the Solid-state by 13C Cross-polarization Magic Angle Spinning NMR."  J. Peptide Sci.  10, 336-341. PMID: 15214438 [PubMed]

4. Henzler Wildman, K. A., Lee, D. K. and Ramamoorthy, A.  (2003)  "Mechanism of Lipid Bilayer Disruption by the Human Antimicrobial Peptide LL-37."  Biochemistry.  42, 6545-6558. PMID:12767238 [PubMed]

3. Henzler Wildman, K. A., Wilson, E. E., Lee, D. K., Ramamoorthy, A.  (2003)  "Determination of the Conformation and Stability of Simple Homopolypeptides Using Solid State NMR."  Solid State NMR.  24, 94-109.PMID: 12943907 [PubMed]

2. Hallock, K. J., Henzler Wildman, K. A., Lee, D. K., and Ramamoorthy, A.  (2002)  "An Innovative Procedure Using a Sublimable Solid to Align Lipid Bilayers for Solid-State NMR."  Biophys J.  82, 2499-2503. PMID: 11964237 [PubMed]

1. Henzler Wildman, K. A., Lee, D. K., and Ramamoorthy, A. (2002)  "Determination of α-Helix and β-Sheet Stability in the Solid State:  A Solid-State NMR Investigation of Poly(L-Alanine)."  Biopolymers.  64, 246-254. PMID: 12115132 [PubMed]

*These authors contributed equally to the work.