Coiled Coil Fusion Proteins Facilitate Structural Studies of the Cardiac Myosin Rod and Thick Filament
Myosin, the motor protein responsible for muscle contraction and ultimately movement, makes up over 40% of the protein mass in muscle. It also has a long history in the lab of biochemistry professor Ivan Rayment, who solved the structure of the protein’s motor domain for the first time in 1993. IPiB student Michael Andreas is one of many in the lab who have carried on the tradition of studying myosin. He’s focused on another part of the protein called the myosin rod, which forms filaments and lacks a high-resolution structure. Through his Ph.D. research, he’s worked to assemble a model of the entire myosin rod by crystallizing different fragments of the protein and compiling them together.
To learn more about his work, attend his Thesis Review at 1 p.m. on Tuesday, July 23 in Room 1211 of the HFD Biochemical Sciences Building.