Mechanisms of G-Quadruplex Unwinding and Repair
In cells, double-stranded DNA must be separated into single-stranded DNA during many genome maintenance processes. Single-stranded DNA can fold into complex structures, such as G-quadruplexes. G-quadruplexes can block replication and must be unfolded for the cell to survive. In the lab of professor James Keck, Andy Voter did his Ph.D. research on RecQ, a protein that unwinds G-quadruplexes. He solved the structure of RecQ bound to an unfolded G-quadruplex and found a pocket in the protein that helps in this unwinding. Andy used this pocket to study how G-quadruplexes help the bacteria that causes gonorrhea.
To learn more about his work, attend his Thesis Review at 2 p.m. on Thursday, April 11 in Room 1211 of the HFD Biochemical Sciences Building.