Movement of the Escherichia coli RNA polymerase clamp modulates intrinsic transcription termination
Transcription is an essential process that creates RNA from DNA. Professor Robert Landick and his lab study the last two parts of transcription in bacteria, called elongation and termination. Michael Bellecourt spent his graduate studies looking at how the molecule that synthesizes the RNA — called RNA polymerase — is involved in termination. He developed experiments that showed how termination occurs in two stages, commitment followed by actual termination, and how a clamp on the RNA polymerase affects termination but does so indirectly by impacting elongation. Transcription is important to understand for other researchers in the Landick Lab and elsewhere who try to fine tune bacteria to create biofuels or look for new antibiotics as bacteria become resistant.
Learn more about his work at his Thesis Review at 1:30 p.m. on Tuesday, Aug. 21 in the Khorana Auditorium of the HFD Biochemistry Laboratories.