Biosynthesis of N-formylated Sugars in Mycobacterium tuberculosis
The Holden Laboratory has had a long history of investigating the structures and functions of enzymes. Haley Brown has focused on two enzymes in particular that produce an unusual sugar in Mycobacterium tuberculosis, the causative agent of tuberculosis. This organism is a successful pathogen because of its ability to persist in immune cells in the lungs, and it is widely recognized as a global health problem. Haley has worked to characterize a pathway utilized by the bacterium to produce an unusual sugar. Her results will stimulate further research into why the bacterium makes the sugar and its possible role in virulence. The work is especially timely given the rise of antibiotic resistance in M. tuberculosis.
Hear about the ins and outs of this pathway at her Thesis Review at 10 a.m. on Friday, Aug. 10 in the Khorana Auditorium of the HFD Biochemistry Laboratories.