Molecular Mechanisms Determining Bacterial Cell Shape: Role of Cardiolipin
Ti-Yu Lin studies a lipid called cardiolipin. Lipids are molecules such as fats and cholesterol. Cardiolipin — first identified from a cow heart, hence the “cardio” name — is also present in the membrane that surrounds bacterial cells. While it has many known functions, Ti-Yu showed in his Ph.D. research a new function for the first time. He revealed that this lipid helps determine cell shape and solved the mechanism of how this happens. Bacteria often rely on their shape to infect hosts, move around, or form biofilms that help them grow their numbers. He says the work could have implications in areas like antibiotic development.
To learn more about his work, attend his Thesis Review at 12 p.m. on Friday, May 25 in the Khorana Auditorium in HFD Biochemistry Laboratories.