The multiple functions of the carboxy-terminal domain (CTD) of RNA polymerase II
Tuesday, September 5th at 3:30PM
Room 1211, HFD Biochemical Sciences Building
Dr. Dirk Eick’s group has developed a combined genetic-mass spectrometric method to study the 240 potential phosphorylation sites in mammalian Pol II CTD. The approach provides access to the type and position of modification in each individual heptad-repeat of CTD. They combine this approach with engineered analog-sensitve kinases (e.g. asCdk9) to study heptad-specific phosphorylation of CTD in vivo. Further they study the heptad-specific binding of Mediator, Integrator and other factors to CTD. The project aims at better understanding of the complex relationship between dynamic changes in chromatin modifications and the activity of the transcription machinery.
Please contact Aseem Ansari if you would lik to meet Prof. Dirk Eick. email@example.com