BIOCHEMISTRY

Baculoviruses manipulate the host DNA damage response and apoptosis to aid virus multiplication

Viruses have evolved to ensure they multiply. So much so that they even take steps to prevent the cells they infect from destroying themselves (and the virus) through apoptosis or utilizing the antiviral DNA damage response — two processes that cells use to stop viral infections. Nate Byers of the Friesen Lab studies the baculoviruses, prolific DNA viruses of insects, which are particularly efficient at seizing control of the host cell and thereby replicate quickly to high levels. For example, he found that the virus actually prevents apoptosis by helping the cell’s own apoptosis inhibitor work better. Hear more about his findings at his Thesis Review at 2:30 p.m. on Wednesday, Aug. 31 in the Khorana Auditorium.